Department of Cardiac Surgery, Children's Hospital Boston and Harvard Medical School, Boston, MA, USA.
J Thorac Cardiovasc Surg. 2012 Nov;144(5):1095-1101.e7. doi: 10.1016/j.jtcvs.2012.07.081. Epub 2012 Aug 28.
We have previously shown that surgical Technical Performance Scores (TPS) are important predictors of early postoperative morbidity across a wide spectrum of procedures and that intraoperative recognition and intervention of residual defects resulted in improved outcomes. We hypothesized that these scores would also be important predictors of midterm outcomes.
Neonates and infants aged younger 6 months were prospectively followed from the index surgery for a minimum of 1 year. The TPS were calculated using previously published criteria, including intraoperative course, predischarge echocardiograms or catheterizations, and clinical data, and graded as optimal, adequate, or inadequate. Case complexity was determined by the Risk Adjustment for Congenital Heart Surgery-1 category. The primary outcome was mortality, and the secondary outcome was the need for unplanned reinterventions. Outcomes were analyzed using nonparametric methods and a logistic regression model.
A total of 166 patients were included in our study, with 7 early deaths. The remaining 159 patients (Risk Adjustment for Congenital Heart Surgery-1 category 4-6, 76 [48%]; neonates, 78 [49%]) were followed for a minimum of 1 year after surgery. There were 14 late deaths or late transplantations and 55 late reinterventions. On univariate analysis, the TPS were associated with mortality (P < .001) and reintervention (P = .04). On logistic regression analysis, inadequate TPS was associated with late mortality (P < .001; odds ratio, 7.2; 95% confidence interval, 2.2-23.6), and Risk Adjustment for Congenital Heart Surgery-1 category (P = .004; odds ratio, 3.7; 1.5-8.8) at index surgery was associated with need for late unplanned reintervention.
Technical performance affects midterm survival after infant heart surgery. Inadequate TPS can be used to prospectively identify patients at ongoing risk of demise and the need for reintervention. An aggressive approach to diagnosing and treating residual lesions at the initial operation is warranted.
我们之前已经证明,手术技术表现评分(TPS)是各种手术术后早期发病率的重要预测因素,术中识别和干预残余缺陷可改善预后。我们假设这些评分也是中期结果的重要预测因素。
前瞻性随访了从索引手术开始年龄小于 6 个月的新生儿和婴儿至少 1 年。TPS 使用先前发表的标准计算,包括术中过程、出院前超声心动图或导管检查以及临床数据,并分为最佳、充分或不足。病例复杂性由先天性心脏病手术风险调整-1 类别决定。主要结局是死亡率,次要结局是需要计划外再次介入。使用非参数方法和逻辑回归模型分析结果。
共有 166 例患者纳入研究,其中 7 例早期死亡。其余 159 例患者(先天性心脏病手术风险调整-1 类别 4-6 级,76 [48%];新生儿,78 [49%])手术后至少随访 1 年。有 14 例晚期死亡或晚期移植,55 例晚期再次介入。单因素分析显示,TPS 与死亡率(P<0.001)和再次介入(P=0.04)相关。逻辑回归分析显示,TPS 不足与晚期死亡率相关(P<0.001;比值比,7.2;95%置信区间,2.2-23.6),索引手术时先天性心脏病手术风险调整-1 类别(P=0.004;比值比,3.7;1.5-8.8)与需要晚期非计划再次介入相关。
技术表现影响婴儿心脏手术后的中期生存。不足的 TPS 可用于前瞻性识别持续存在死亡风险和再次介入需求的患者。在初始手术中积极诊断和治疗残余病变是必要的。