Nathan Meena, Gauvreau Kimberlee, Liu Hua, Pigula Frank A, Mayer John E, Colan Steven D, Del Nido Pedro J
Department of Cardiac Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
J Thorac Cardiovasc Surg. 2014 Dec;148(6):2540-6.e1-5. doi: 10.1016/j.jtcvs.2014.07.073. Epub 2014 Aug 4.
In a previous study of infants less than 6 month old, we found that delayed revision of residual lesions resulted in worse patient outcomes compared with intraoperative revision. We explored a larger cohort to determine if this finding persisted.
A prospective cohort followed from index surgery to discharge from January 2011 to September 2013 were divided into 4 groups: (1) intraoperative revisions (IO) of residual lesions, (2) delayed postoperative revision (PO) of residual lesions during the same hospital stay, (3) both intraoperative and delayed (BOTH) revision of residual lesions, (4) no intraoperative or postoperative revision (NO). Linear and logistic regression analyses were used to compare outcomes of postoperative hospital length of stay, postoperative adverse events (AE), hospital costs, and mortality, after adjusting for age, prematurity, presence of extracardiac anomalies, and RACHS-1 (Risk Adjustment for Congenital Heart Surgery-1) risk category known to affect outcomes.
Of the 2427 patients discharged after a congenital cardiac operation, 1886 were eligible for this study after exclusion of adults, procedures performed off cardiopulmonary bypass, and transplants and assist devices. On multivariable modeling adjusting for other significant patient factors, the NO group fared better than the other 3 groups. The IO group had significantly lower postoperative length of stay, AE rate, and hospital costs compared with the PO and BOTH groups, but showed no significant differences in mortality.
Intraoperative correction of residual lesions results in shorter length of stay, and lower postoperative AE and costs compared with delayed postoperative revision of residual lesions.
在一项针对6个月以下婴儿的先前研究中,我们发现与术中修复相比,残余病变延迟修复会导致患者预后更差。我们研究了一个更大的队列,以确定这一发现是否仍然成立。
对2011年1月至2013年9月从首次手术到出院的前瞻性队列进行研究,将其分为4组:(1)残余病变的术中修复(IO);(2)同一住院期间残余病变的术后延迟修复(PO);(3)残余病变的术中及延迟修复(BOTH);(4)无术中或术后修复(NO)。在调整已知会影响预后的年龄、早产、心外畸形的存在以及先天性心脏病手术风险调整-1(RACHS-1)风险类别后,使用线性和逻辑回归分析比较术后住院时间、术后不良事件(AE)、医院费用和死亡率的预后。
在先天性心脏手术后出院的2427例患者中,排除成人、非体外循环下进行的手术以及移植和辅助装置后,1886例符合本研究条件。在对其他重要患者因素进行多变量建模调整后,NO组的预后优于其他3组。与PO组和BOTH组相比,IO组的术后住院时间、AE发生率和医院费用显著更低,但在死亡率方面无显著差异。
与残余病变的术后延迟修复相比,残余病变的术中矫正可导致住院时间缩短、术后AE减少和费用降低。