Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, School of Chemical and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, China.
Int J Biol Macromol. 2012 Dec;51(5):1121-6. doi: 10.1016/j.ijbiomac.2012.08.030. Epub 2012 Aug 31.
Chitin/alginate (CA) blend membranes were successfully prepared from 8 wt% NaOH/4 wt% urea aqueous solution by coagulating with 0.5M CaCl(2) aqueous solution containing 5 wt% HCl. Morphology, mechanical properties, thermal stability, and antimicrobial effects of the membranes were investigated by scanning electron microscopy, IR and UV spectroscopes, X-ray diffraction, tensile tests, thermogravimetric analysis, water swelling and antimicrobial tests. The CA blends were miscible when the content of alginate was range from 33 to 67 wt%. The crystallinity of the blend membranes decreased with an increase of alginate. Comparing with chitin membranes, the tensile strength and breaking elongation of the blend membranes were obviously improved in dry and wet states. The best values of the tensile strength and breaking elongation were 48 MPa and 27%, respectively. All the blend membranes still retained obvious antimicrobial effects toward S. aureus and E. coli. Therefore, they showed potential for biomedical application.
壳聚糖/海藻酸钠（CA）共混膜是由 8wt%NaOH/4wt%尿素水溶液在 0.5M 含 5wt%HCl 的 CaCl2 水溶液中凝固而成。通过扫描电子显微镜、红外和紫外光谱仪、X 射线衍射、拉伸试验、热重分析、水膨胀和抗菌试验研究了膜的形态、力学性能、热稳定性和抗菌效果。当海藻酸钠的含量在 33 到 67wt%范围内时，CA 共混物是可混溶的。共混膜的结晶度随海藻酸钠含量的增加而降低。与壳聚糖膜相比，共混膜在干燥和湿润状态下的拉伸强度和断裂伸长率均有明显提高。拉伸强度和断裂伸长率的最佳值分别为 48MPa 和 27%。所有共混膜对金黄色葡萄球菌和大肠杆菌仍保持明显的抗菌效果。因此，它们具有潜在的生物医学应用价值。
