Department of Psychiatry, Korea University, College of Medicine, Seoul, Republic of Korea.
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:62-9. doi: 10.1016/j.pnpbp.2012.08.009. Epub 2012 Aug 23.
The P300 is a useful psychophysiological index that reflects cognitive functions; however, the relationship between P300 indices and neuropsychological tests in Alzheimer's disease (AD) patients is unclear.
Thirty-one AD patients and 31 elderly normal control (NC) subjects were recruited. Age and education level were matched between the two groups. The relationship between the P300 and the Korean version of the Consortium to Establish a Registry for Alzheimer's disease (CERAD-K) assessment packet (including 11 neuropsychological tests) was examined in AD patients.
Compared to the NC subjects, the AD patients exhibited significantly decreased P300 amplitudes; however, there was no significant difference between the two groups in terms of P300 latency. After a permutation-based correction for multiple tests, P300 amplitudes at the Cz and Pz electrodes were significantly correlated with performance on the word list recognition, constructional praxis, and word fluency neuropsychological tests in the AD patients. Additionally, P300 latencies at the Pz and C6 electrodes were also significantly correlated with performance on the Mini-Mental State Examination, CERAD-K version (MMSE-K), and Trail Making Test part A (TMT-A) neuropsychological tests in the AD patients.
The results suggest that the P300 is responsive to the deterioration of language, memory, and executive functions observed in AD patients. Although there was no significant difference between the AD patients and NC subjects in the P300 latency, P300 latency has been shown to reflect impaired global cognition and attention deficits associated with AD. Our results suggest that P300 indices could be used as biological markers that indicate impaired neuropsychological functions in AD patients.
P300 是一种有用的心理生理指标，反映认知功能；然而，P300 指标与阿尔茨海默病（AD）患者神经心理学测试之间的关系尚不清楚。
招募了 31 名 AD 患者和 31 名老年正常对照（NC）受试者。两组的年龄和教育水平相匹配。在 AD 患者中，检查了 P300 与韩国版 Consortium to Establish a Registry for Alzheimer's disease（CERAD-K）评估包（包括 11 项神经心理学测试）之间的关系。
与 NC 受试者相比，AD 患者的 P300 波幅明显降低；然而，两组之间的 P300 潜伏期没有显著差异。经过多次测试的置换检验校正后，AD 患者 Cz 和 Pz 电极的 P300 波幅与单词识别、结构实践和单词流畅性神经心理学测试的表现显著相关。此外，AD 患者 Pz 和 C6 电极的 P300 潜伏期也与 Mini-Mental State Examination、CERAD-K 版本（MMSE-K）和 Trail Making Test 部分 A（TMT-A）神经心理学测试的表现显著相关。
结果表明，P300 对 AD 患者语言、记忆和执行功能的恶化有反应。尽管 AD 患者和 NC 受试者之间的 P300 潜伏期没有显著差异，但 P300 潜伏期已被证明反映了与 AD 相关的整体认知和注意力缺陷受损。我们的结果表明，P300 指数可用作生物标志物，指示 AD 患者神经心理功能受损。
