Science Education Center and Graduate Institute of Science Education, National Taiwan Normal University, Taiwan, ROC.
Brain Cogn. 2012 Nov;80(2):282-9. doi: 10.1016/j.bandc.2012.06.005. Epub 2012 Aug 31.
The contribution of genetic factors to the memory is widely acknowledged. Research suggests that these factors include genes involved in the dopaminergic pathway, as well as the genes for brain-derived neurotrophic factor (BDNF) and methylenetetrahydrofolate reductase (MTHFR). The activity of the products of these genes is affected by single nucleotide polymorphisms (SNPs) within the genes. This study investigates the association between memory and SNPs in genes involved in the dopaminergic pathway, as well as in the BDNF and MTHFR genes, in a sample of healthy individuals. The sample includes 134 Taiwanese undergraduate volunteers of similar cognitive ability. The Chinese versions of the Wechsler Memory Scale (WMS-III) and Wechsler Adult Intelligence Scale (WAIS-III) were employed. Our findings indicate that the BDNF Met66Val polymorphism and dopamine receptor D3 (DRD3) Ser9Gly polymorphism are associated significantly with long-term auditory memory. Further analysis detects no significant associations in the other polymorphisms and indices. Future replicated studies with larger sample sizes, and studies that consider different ethnic groups, are encouraged.
遗传因素对记忆的贡献是被广泛认可的。研究表明，这些因素包括涉及多巴胺能途径的基因，以及脑源性神经营养因子（BDNF）和亚甲基四氢叶酸还原酶（MTHFR）的基因。这些基因产物的活性受到基因内单核苷酸多态性（SNPs）的影响。本研究在一组健康个体中调查了与多巴胺能途径相关基因以及 BDNF 和 MTHFR 基因中的 SNPs 与记忆之间的关联。该样本包括 134 名认知能力相似的台湾本科志愿者。使用了韦氏记忆量表（WMS-III）和韦氏成人智力量表（WAIS-III）的中文版本。我们的发现表明，BDNF Met66Val 多态性和多巴胺受体 D3（DRD3）Ser9Gly 多态性与长期听觉记忆显著相关。进一步的分析在其他多态性和指数中未检测到显著关联。鼓励进行具有更大样本量的重复研究，并考虑不同种族群体的研究。
