Chang Yun-Hsuan, Wang Tzu-Yun, Lee Sheng-Yu, Chen Shiou-Lan, Huang Chih-Chun, Chen Po See, Yang Yen Kuang, Hong Jau-Shyong, Lu Ru-Band
Department of Psychology, College of Medical and Health Science, Asia University, Taichung, Taiwan.
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Front Genet. 2018 Nov 27;9:583. doi: 10.3389/fgene.2018.00583. eCollection 2018.
Studies suggest that a functional polymorphism of brain-derived neurotrophic factor (BDNF), polymorphism affects cognitive functions, however, the effect is unclear in bipolar II (BD-II) disorder. We used the Wechsler Memory Scale-third edition (WMS-III), the presence of the polymorphism, and plasma concentrations of BDNF to investigate the association between memory impairment and BDNF in BD-II disorder. We assessed the memory functions of 228 BD-II patients and 135 healthy controls (HCs). BD-II patients had significantly lower scores on five of the eight WMS-III subscales. In addition to education, the BDNF polymorphism were associated with the following subscales of WMS-III, auditory delayed memory, auditory delayed recognition memory and general memory scores in BD-II patients, but not in HC. Moreover, BD-II patients with the -homozygote scored significantly higher on the visual immediate memory subscale than did those with the and polymorphisms. The significantly positive effect of the -homozygote did not have a significantly positive effect on memory in the HC group, however. We found no significant association between BDNF polymorphisms and plasma concentrations of BDNF. The plasma BDNF was more likely to be associated with clinical characteristics than it was with memory indices in the BD-II group. The impaired memory function in BD-II patients might be dependent upon the association between the polymorphism and peripheral BDNF levels.
研究表明，脑源性神经营养因子（BDNF）的功能多态性会影响认知功能，然而，其在双相II型障碍（BD-II）中的作用尚不清楚。我们使用韦氏记忆量表第三版（WMS-III）、该多态性的存在以及BDNF的血浆浓度来研究BD-II障碍中记忆损害与BDNF之间的关联。我们评估了228例BD-II患者和135名健康对照者（HCs）的记忆功能。BD-II患者在WMS-III的八个分量表中的五个上得分显著更低。除了受教育程度外，BDNF多态性与BD-II患者WMS-III的以下分量表相关，即听觉延迟记忆、听觉延迟识别记忆和总体记忆得分，但在HC中并非如此。此外，携带-homozygote的BD-II患者在视觉即时记忆分量表上的得分显著高于携带和多态性的患者。然而，-homozygote的显著正向作用在HC组对记忆并没有显著的正向影响。我们发现BDNF多态性与BDNF的血浆浓度之间没有显著关联。在BD-II组中，血浆BDNF更可能与临床特征相关，而非与记忆指标相关。BD-II患者的记忆功能受损可能取决于多态性与外周BDNF水平之间的关联。
