HIV 感染者乙型肝炎病毒管理和治疗：卫生保健专业人员实用指南。
Management and treatment of hepatitis B virus in patients with HIV infection: A practical guide for health care professionals.
机构信息
Division of Infectious Diseases and Immunodeficiency Service, McGill University Health Centre;
出版信息
Can J Infect Dis Med Microbiol. 2011 Fall;22(3):88-96. doi: 10.1155/2011/686918.
The management and treatment of HIV and hepatitis B virus (HBV)-coinfected patients present specific challenges for clinicians. The morbidity and mortality related to these concomitant infections are growing concerns, while the use of antiviral drugs effective against both viruses complicates therapeutic decision making. The present document provides guidelines for physicians regarding care and treatment of patients coinfected with HIV and HBV. Primary prevention of HBV in HIV-positive patients is achieved through appropriate vaccination schedules. Follow-up before treatment of HBV may include liver biopsy, screening for hepatocellular carcinoma and testing for esophageal varicies in cases of cirrhosis. In HBV-infected patients requiring treatment, recommendations regarding initiation, duration and choice of first-line drugs are made. Finally, in the case of resistance, appropriate alternative therapies are necessary.
HIV 和乙型肝炎病毒（HBV）合并感染患者的管理和治疗对临床医生提出了特殊挑战。这些合并感染相关的发病率和死亡率令人担忧，而同时使用针对这两种病毒均有效的抗病毒药物则使治疗决策复杂化。本文件为医生提供了有关 HIV 和 HBV 合并感染患者的护理和治疗指南。通过适当的疫苗接种计划实现对 HIV 阳性患者的 HBV 初级预防。HBV 治疗前的随访检查可能包括肝活检、肝癌筛查和肝硬化患者的食管静脉曲张检测。对于需要治疗的 HBV 感染患者，建议启动治疗、治疗持续时间和一线药物选择。最后，在出现耐药的情况下，需要选择适当的替代治疗方案。
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