结直肠癌：病理方面。
Colorectal carcinoma: Pathologic aspects.
机构信息
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA.
出版信息
J Gastrointest Oncol. 2012 Sep;3(3):153-73. doi: 10.3978/j.issn.2078-6891.2012.030.
Abstract
Colorectal carcinoma is one of the most common cancers and one of the leading causes of cancer-related death in the United States. Pathologic examination of biopsy, polypectomy and resection specimens is crucial to appropriate patient managemnt, prognosis assessment and family counseling. Molecular testing plays an increasingly important role in the era of personalized medicine. This review article focuses on the histopathology and molecular pathology of colorectal carcinoma and its precursor lesions, with an emphasis on their clinical relevance.
摘要
结直肠癌是美国最常见的癌症之一，也是癌症相关死亡的主要原因之一。对活检、息肉切除术和切除标本进行病理检查对于适当的患者管理、预后评估和家庭咨询至关重要。分子检测在个性化医疗时代发挥着越来越重要的作用。本文重点介绍了结直肠癌及其前体病变的组织病理学和分子病理学，并强调了它们的临床相关性。
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Lynch syndrome: clinical, pathological, and genetic insights.林奇综合征：临床、病理和遗传学见解。
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Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths.结肠镜息肉切除术与结直肠癌死亡的长期预防。
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Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications.分子途径：结直肠癌中的微卫星不稳定性：预后、预测和治疗意义。
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Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis.黏液型亚型作为结直肠癌的预后因素：系统评价和荟萃分析。
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Rate of residual disease after complete endoscopic resection of malignant colonic polyp.完全内镜切除恶性结肠息肉后的残留疾病率。
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Juvenile polyposis syndrome.幼年性息肉病综合征。
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Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline.使用靶向评估和基因检测识别林奇综合征高危个体：美国国家遗传咨询师协会与美洲遗传性结直肠癌协作组联合实践指南
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Individuals with sessile serrated polyps express an aggressive colorectal phenotype.有无蒂锯齿状息肉的个体表现出侵袭性结直肠表型。
Dis Colon Rectum. 2011 Oct;54(10):1216-23. doi: 10.1097/DCR.0b013e318228f8a9.
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CA Cancer J Clin. 2011 Jul-Aug;61(4):212-36. doi: 10.3322/caac.20121. Epub 2011 Jun 17.
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