J Gastrointest Oncol. 2012 Sep;3(3):226-31. doi: 10.3978/j.issn.2078-6891.2012.026.
Accumulating epidemiological studies have supported the link between increased body mass index, central obesity and esophageal adenocarcinoma. This association appears stronger than that for other types of obesity-related cancers. Central obesity or visceral fat, more often observed in men, is much more strongly associated with adenocarcinoma than body mass index alone, possibly contributing to the imbalance of disease occurrence between the sexes. Potential mechanisms underlying the association between obesity and esophageal adenocarcinoma have been recently identified, including the insulin-like growth factor pathway, adipokines and sex hormone disturbances. These findings are summarized in this review; however, more research is warranted before these mechanisms are conclusively established.
越来越多的流行病学研究支持身体质量指数增加、中心性肥胖与食管腺癌之间的关联。这种关联似乎比其他类型的肥胖相关癌症更为强烈。中心性肥胖或内脏脂肪在男性中更为常见，与腺癌的关联比单纯的身体质量指数更为密切，可能导致男女之间疾病发生的不平衡。肥胖与食管腺癌之间关联的潜在机制最近已经被确定，包括胰岛素样生长因子途径、脂肪因子和性激素紊乱。这些发现都在这篇综述中进行了总结；然而，在这些机制被最终确定之前，还需要更多的研究。
