State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China.
J Insect Sci. 2012;12:40. doi: 10.1673/031.012.4001.
Transcription factors are present in all living organisms, and play vital roles in a wide range of biological processes. Studies of transcription factors will help reveal the complex regulation mechanism of organisms. So far, hundreds of domains have been identified that show transcription factor activity. Here, 281 reported transcription factor domains were used as seeds to search the transcription factors in genomes of Bombyx mori L. (Lepidoptera: Bombycidae) and four other model insects. Overall, 666 transcription factors including 36 basal factors and 630 other factors were identified in B. mori genome, which accounted for 4.56% of its genome. The silkworm transcription factors' expression profiles were investigated in relation to multiple tissues, developmental stages, sexual dimorphism, and responses to oral infection by pathogens and direct bacterial injection. These all provided rich clues for revealing the transcriptional regulation mechanism of silkworm organ differentiation, growth and development, sexual dimorphism, and response to pathogen infection.
转录因子存在于所有生物中，在广泛的生物过程中发挥着至关重要的作用。对转录因子的研究将有助于揭示生物的复杂调控机制。迄今为止，已经鉴定出数百个具有转录因子活性的结构域。在这里，我们使用 281 个已报道的转录因子结构域作为种子，在家蚕（鳞翅目：家蚕科）和其他四种模式昆虫的基因组中搜索转录因子。总的来说，在 B. mori 基因组中鉴定出了 666 种转录因子，包括 36 种基础因子和 630 种其他因子，占其基因组的 4.56%。我们研究了家蚕转录因子的表达谱与多种组织、发育阶段、性别二态性以及对病原体的口服感染和直接细菌注射的反应之间的关系。所有这些都为揭示家蚕器官分化、生长发育、性别二态性和对病原体感染的转录调控机制提供了丰富的线索。
