神经心理学表现对有和无 HIV 的老年和年轻成年人日常功能的影响。
The impact of neuropsychological performance on everyday functioning between older and younger adults with and without HIV.
机构信息
School of Nursing, University of Alabama at Birmingham, AL, USA.
出版信息
J Assoc Nurses AIDS Care. 2013 Mar-Apr;24(2):112-25. doi: 10.1016/j.jana.2012.05.002. Epub 2012 Sep 1.
Abstract
In this cross-sectional study, a community-based sample of 162 younger and older adults with and without HIV was compared on neuropsychological and everyday-functioning measures. In the HIV sample, the relationship between cognition, everyday functioning, and HIV biomarkers was also examined. A battery of cognitive tests was completed along with two laboratory measures of everyday functioning and one measure of HIV medication adherence. Main effects for age and HIV were found on several neuropsychological measures and on the Timed Instrumental Activities of Daily Living test; those who were older or who had HIV exhibited poorer performance. Although age-by-HIV interactions were not observed, older adults with HIV as a group performed worse on eight out of the nine neuropsychological and everyday functioning measures. Few of these neuropsychological and everyday measures were related to HIV biomarkers (e.g., CD4+ T cell count). Implications for nursing practice and research are posited.
摘要
在这项横断面研究中，比较了 162 名年龄在 HIV 阳性和阴性的年轻和年长成年人的神经心理学和日常功能测量值。在 HIV 样本中，还检查了认知、日常功能和 HIV 生物标志物之间的关系。完成了一系列认知测试以及两项日常功能的实验室测量和一项 HIV 药物依从性测量。年龄和 HIV 在几个神经心理学测量和计时工具性日常生活活动测试上存在主要影响；年龄较大或感染 HIV 的人表现较差。虽然没有观察到年龄与 HIV 的相互作用，但 HIV 阳性的老年人在九项神经心理学和日常功能测量中有八项表现更差。这些神经心理学和日常措施很少与 HIV 生物标志物（例如 CD4+T 细胞计数）有关。提出了对护理实践和研究的影响。
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