Mokrowiecka Anna, Daniel Piotr, Jasinska Anna, Pietruczuk Miroslawa, Pawlowski Maciej, Szczesniak Piotr, Orszulak-Michalak Daria, Malecka-Panas Ewa
Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
Hepatogastroenterology. 2012 Nov-Dec;59(120):2395-9. doi: 10.5754/hge12587.
BACKGROUND/AIMS: Central obesity is a risk factor for GERD, Barrett's esophagus and esophageal adeno-carcinoma. Recent studies have suggested that adipocytokines are the possible link between adiposity and Barrett's carcinogenesis. To determine the adiponectin, resistin and leptin concentration as well as the central adiposity parameters in BE patients with and without intestinal metaplasia (IM) in comparison to GERD and healthy controls.
Total of 77 patients (30 patients with GERD, 26 BE with IM and 21 BE without IM) and 30 healthy controls were investigated for the central obesity parameters. Serum levels of adipocytokines were measured with ELISA.
The serum concentration of adiponectin was significantly lower in BE compared to those in GERD and to controls (p<0.001). Levels of leptin was slightly higher in BE than in GERD and controls (NS). Level of resistin was significantly higher in GERD compared to both control and BE patients (p<0.001). Waist circumference, WHR and WTR were significantly higher in BE patients compared to GERD (p<0.001) and to control group (p<0.001).
Features of central obesity rather than BMI are associated with BE development. Adipokines may be important at the early step of BE development, before the IM occurrence.
背景/目的：中心性肥胖是胃食管反流病（GERD）、巴雷特食管和食管腺癌的危险因素。最近的研究表明，脂肪细胞因子可能是肥胖与巴雷特癌变之间的联系。为了确定与GERD患者和健康对照相比，有和没有肠化生（IM）的巴雷特食管（BE）患者的脂联素、抵抗素和瘦素浓度以及中心性肥胖参数。
共对77例患者（30例GERD患者、26例伴有IM的BE患者和21例不伴有IM的BE患者）和30例健康对照进行了中心性肥胖参数调查。采用酶联免疫吸附测定法（ELISA）测量血清脂肪细胞因子水平。
与GERD患者和对照组相比，BE患者血清脂联素浓度显著降低（p<0.001）。BE患者的瘦素水平略高于GERD患者和对照组（无统计学意义）。与对照组和BE患者相比，GERD患者的抵抗素水平显著升高（p<0.001）。与GERD患者相比，BE患者的腰围、腰臀比和腰高比显著更高（p<0.001），与对照组相比也显著更高（p<0.001）。
中心性肥胖特征而非体重指数（BMI）与BE的发生有关。在IM出现之前，脂肪细胞因子可能在BE发生的早期阶段起重要作用。
