Department of Cell and Developmental Biology, University College London, UK.
Curr Opin Cell Biol. 2012 Oct;24(5):677-84. doi: 10.1016/j.ceb.2012.08.002. Epub 2012 Sep 1.
Immunity, embryogenesis and tissue repair rely heavily on cell migration. Cells can be seen migrating as individuals or large groups. In the latter case, collectiveness emerges via cell-cell interactions. In migratory epithelial cell sheets, classic Cadherins are critical to maintain tissue integrity, to promote coordination and establish cell polarity. However, recent evidence indicates that mesenchymal cells, migrating in streams such as neural crest or cancer cells, also exhibit collective migration. Here we will explore the idea that Cadherins play an essential role during collective migration of mesenchymal cells.
免疫、胚胎发生和组织修复在很大程度上依赖于细胞迁移。细胞可以作为个体或大群体进行迁移。在后一种情况下，通过细胞-细胞相互作用会出现集体性。在迁移的上皮细胞片中，经典的钙黏蛋白对于维持组织完整性、促进协调和建立细胞极性至关重要。然而，最近的证据表明，在间质细胞的集体迁移中，如神经嵴或癌细胞，也表现出集体迁移。在这里，我们将探讨钙黏蛋白在间质细胞的集体迁移中发挥重要作用的观点。
