理性设计南极假丝酵母脂肪酶 B 用于二醇的选择性单酯化反应。
Rational engineering of Candida antarctica lipase B for selective monoacylation of diols.
机构信息
School of Biotechnology, Department of Biochemistry, Royal Institute of Technology (KTH), AlbaNova, SE-106 91 Stockholm, Sweden.
出版信息
Chem Commun (Camb). 2012 Oct 14;48(80):10013-5. doi: 10.1039/c2cc34684b.
PMID:22945018
Abstract
The enzyme Candida antarctica lipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations.
摘要
通过分子建模，对南极假丝酵母脂肪酶 B 进行了定点突变。突变的结果是，该酶对一系列二醇的选择性高于相应的单酯。
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