可视化 DNA 损伤反应的全球效应。
Visualizing global effects of the DNA damage response.
机构信息
MRC National Institute for Medical Research, Division of Stem Cell Biology and Developmental Genetics, Mill Hill, London NW7 1AA, UK.
出版信息
Nat Cell Biol. 2012 Sep;14(9):900-1. doi: 10.1038/ncb2571.
DOI:10.1038/ncb2571
PMID:22945255
Abstract
In a large-scale analysis, the effects of DNA damage on the levels and localization of almost every protein in an organism have now been tracked in living cells. It is shown that that although many proteins change their position or concentration, they rarely do both.
摘要
在一项大规模分析中，现在已经在活细胞中追踪了 DNA 损伤对生物体中几乎每种蛋白质的水平和定位的影响。结果表明，尽管许多蛋白质改变了它们的位置或浓度，但它们很少同时改变两者。
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