由 SPRTN 介导的停滞复制叉处 DNA 损伤反应的激活模型。
A model of DNA damage response activation at stalled replication forks by SPRTN.
机构信息
IFOM (Istituto FIRC di Oncologia Molecolare), Via Adamello 16, 20139, Milan, Italy.
Università degli Studi di Milano, 20122, Milan, Italy.
出版信息
Nat Commun. 2019 Dec 12;10(1):5671. doi: 10.1038/s41467-019-13610-7.
Abstract
The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.
摘要
DNA 复制过程受到许多因素的威胁，包括 DNA 损伤和作为障碍的机器。在这里，我们讨论并推测了一种最近提出的机制，即在 DNA 复制叉的进展受到挑战的情况下，该机制能够激活 DNA 损伤反应以应对损伤。
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