IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, P.O. Box 9, 00014, Helsinki, Finland.
J Behav Med. 2013 Dec;36(6):583-90. doi: 10.1007/s10865-012-9452-y. Epub 2012 Sep 4.
The serotonin system has been shown to be involved in the regulation of hostility, anger, and aggressive behavior. Previous molecular genetic studies suggest that the serotonin receptor 1B (HTR1B) rs6296 genotype might have a particular role in these types of behaviors. We examined whether HTR1B is related to hostility, anger, and aggressive behavior phenotypes over a lifespan and whether it modifies the connection between childhood aggressive behavior and adulthood hostility and anger. The participants were 967 women and men from a large population based sample (The Young Finns Study) with a 27-year follow-up. Childhood aggressive behavior was reported by the mother twice when the participants were 3 to 12 years of age. Adulthood hostility and anger were self-reported by the participants between ages 24 and 36. Childhood aggressive behavior predicted adulthood hostility over 27 years. HTR1B SNP rs6296 was associated with childhood aggressive behavior but not with adulthood anger or hostility. The HTR1B SNP rs6296 modified the association between childhood aggressive behavior and adulthood hostility. Aggressive behavior and hostility might form a life course pattern, and the HTR1B might contribute to a development of this pattern.
血清素系统被证明参与了敌意、愤怒和攻击行为的调节。先前的分子遗传学研究表明，血清素受体 1B（HTR1B）rs6296 基因型可能在这些类型的行为中具有特殊作用。我们研究了 HTR1B 是否与一生中的敌意、愤怒和攻击行为表型有关，以及它是否改变了儿童期攻击行为与成年期敌意和愤怒之间的联系。参与者是来自一个大型基于人群的样本（年轻芬兰人研究）的 967 名女性和男性，随访时间为 27 年。当参与者 3 至 12 岁时，母亲两次报告了他们的儿童期攻击行为。成年期的敌意和愤怒是由参与者在 24 至 36 岁之间自我报告的。27 年来，儿童期攻击行为预测了成年期的敌意。HTR1B SNP rs6296 与儿童期攻击行为有关，但与成年期愤怒或敌意无关。HTR1B SNP rs6296 改变了儿童期攻击行为与成年期敌意之间的关联。攻击行为和敌意可能形成一种生活轨迹模式，而 HTR1B 可能有助于这种模式的发展。
