Chandnani V P, Beltran J, Morris C S, Khalil S N, Mueller C F, Burk J M, Bennett W F, Shaffer P B, Vasila M S, Reese J
Department of Radiology, Ohio State University, Columbus 43210.
Radiology. 1990 Jan;174(1):233-6. doi: 10.1148/radiology.174.1.2294554.
Acute experimental osteomyelitis and abscesses were induced in the proximal tibia and surrounding soft tissues, respectively, in 67 New Zealand white rabbits. Fifty-three rabbits were injected with a Staphylococcus aureus solution and 26, with sterile saline in tibial medullae and/or surrounding soft tissues. Contrast material-enhanced computed tomography (CT) and magnetic resonance (MR) imaging were performed 7 days after inoculation. Immediately after imaging, the animals were killed and necropsy was performed. MR imaging was more sensitive than CT in the detection of osteomyelitis (94% vs 66%, P less than .025) and abscesses (97% vs 52%, P less than .001). MR imaging was equally specific as CT in the exclusion of osteomyelitis (93% vs 97%, chi 2 = 0) but less specific than CT in the exclusion of abscesses (77% vs 100%, P less than .025). The overall accuracy of MR imaging was somewhat, although not significantly, greater than that of CT in the detection of both osteomyelitis (93% vs 80%) and abscesses (87% vs 75%).
在67只新西兰白兔中，分别在胫骨近端和周围软组织诱发急性实验性骨髓炎和脓肿。53只兔子在胫骨骨髓腔和/或周围软组织注射金黄色葡萄球菌溶液，26只注射无菌盐水。接种7天后进行对比剂增强计算机断层扫描（CT）和磁共振（MR）成像。成像后立即处死动物并进行尸检。在检测骨髓炎方面，MR成像比CT更敏感（94%对66%，P<0.025），在检测脓肿方面也是如此（97%对52%，P<0.001）。在排除骨髓炎方面，MR成像与CT具有同等特异性（93%对97%，χ2=0），但在排除脓肿方面比CT特异性低（77%对100%，P<0.025）。在检测骨髓炎（93%对80%）和脓肿（87%对75%）方面，MR成像的总体准确性虽然没有显著高于CT，但略高于CT。
