Department of Family and Community Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Int J Obes (Lond). 2013 Jan;37(1):79-85. doi: 10.1038/ijo.2012.126. Epub 2012 Sep 4.
Studies of school-based anti-obesity interventions have yielded inconsistent results. Using growth screening data from a school administrative database, we re-evaluated an obesity prevention strategy that was previously reported to have a beneficial effect on weight status of a sample of students in grades 5-7.
Ten K-8 schools (five control and five intervention) participated in a 2-year cluster-randomized trial of a multi-component nutrition education intervention. We obtained student height and weight data for 6 consecutive school years and imputed missing baseline and follow-up measurements (53% and 55%, respectively) and defined the target population based on the intent-to-treat principle. We analyzed changes in body mass index (BMI) Z-scores via mixed-effects linear regression and in the prevalence of overweight/obesity via conditional logistic regression. We also assessed incidence and remission of overweight/obesity and long-term effects.
We analyzed data for 8186 (96%) K-8 students in the 10 schools (4511 in intervention; 3675 in control). From baseline to the end of the intervention period, mean increases in BMI Z-score were 0.10 and 0.09 in the control and intervention groups, respectively (P=0.671). The prevalence of overweight/obesity increased by 3% in both groups (P=0.926). There was no significant intervention effect on the incidence or remission of overweight/obesity. Among 5469 students who attended study schools during both years of the intervention, there was no significant intervention effect. Furthermore, there was no long-term effect among students with up to 2 years of data beyond the end of the intervention.
Using routinely collected data for the entire target population, we failed to confirm earlier findings of an intervention effect observed in a subset of students in grades 5-7. Volunteer bias in the prior evaluation and/or measurement error in the routinely collected data are potential reasons for the discrepant findings.
基于学校的肥胖干预研究结果并不一致。本研究利用学校行政数据库中的生长筛查数据,重新评估了先前报道的一种肥胖预防策略,该策略对 5-7 年级学生的体重状况有有益影响。
10 所 K-8 学校(5 所对照,5 所干预)参与了一项为期 2 年的多组分营养教育干预的群组随机试验。我们获得了 6 个连续学年的学生身高和体重数据,并对缺失的基线和随访测量值进行了插补(分别为 53%和 55%),并根据意向治疗原则定义了目标人群。我们通过混合效应线性回归分析体重指数(BMI)Z 分数的变化,通过条件逻辑回归分析超重/肥胖的患病率。我们还评估了超重/肥胖的发生率和缓解率以及长期效果。
我们分析了 10 所学校 8186 名(96%)K-8 学生(干预组 4511 名,对照组 3675 名)的数据。从基线到干预结束,对照组和干预组的 BMI Z 分数平均分别增加了 0.10 和 0.09(P=0.671)。两组的超重/肥胖患病率均增加了 3%(P=0.926)。干预对超重/肥胖的发生率和缓解率没有显著影响。在 5469 名参加了干预两年的研究学校的学生中,没有显著的干预效果。此外,在干预结束后,最多有 2 年的数据也没有长期效果。
使用整个目标人群的常规收集数据,我们未能证实先前在 5-7 年级部分学生中观察到的干预效果。先前评估中的志愿者偏差和/或常规收集数据中的测量误差可能是导致结果不一致的原因。