Singh Rana G, Rathore Surendra S, Kumar Rajesh, Agarwal Aruna, Dubey Govind P
Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Indian J Med Sci. 2010 Aug;64(8):378-84.
Present study aimed to study effect of Salacia Chinensis, a herbal drug, on stabilization of renal functions, and markers of endothelial dysfunction in diabetic chronic kidney disease (CKD) patients.
30 stable diabetic CKD patients were randomized into 2 groups; group A and B of 15 patients each. Group A was given trial drug Salacia chinensis 1000 mg twice-daily while group B received placebo. Measures of renal function: Serum creatinine and creatinine clearance; markers of endothelial dysfunction: Interleukin-6 and serum Homocysteine, and lipid profile were measured at baseline and during follow-up period of 6 months.
There was stabilization of renal function as measured by serum creatinine and creatinine clearance in patients who received Salacia Chinensis compared to placebo (P value < 0.05), suggesting that Salacia chinensis may retard the progression of chronic kidney disease. Similarly, there was significant decline in both serum homocysteine and IL-6 levels. [P value < 0.05 for both].
This pilot study showed a promising role for Salacia chinensis as a renoprotective drug, but further prospective studies involving large number of patients are needed to confirm this and also to delineate possible mechanisms.
本研究旨在探讨中药匙羹藤对糖尿病慢性肾脏病（CKD）患者肾功能稳定及内皮功能障碍标志物的影响。
30例病情稳定的糖尿病CKD患者随机分为2组；A组和B组各15例。A组患者每日两次服用试验药物匙羹藤1000毫克，而B组接受安慰剂。检测肾功能指标：血清肌酐和肌酐清除率；内皮功能障碍标志物：白细胞介素-6和血清同型半胱氨酸，并在基线及6个月随访期测量血脂谱。
与安慰剂相比，接受匙羹藤治疗的患者血清肌酐和肌酐清除率所测得的肾功能得到稳定（P值<0.05），表明匙羹藤可能延缓慢性肾脏病的进展。同样，血清同型半胱氨酸和白细胞介素-6水平均显著下降。[两者P值均<0.05]。
这项初步研究表明匙羹藤作为一种肾脏保护药物具有潜在作用，但需要进一步开展涉及大量患者的前瞻性研究来证实这一点，并阐明可能的机制。
