Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
J Cell Biol. 2012 Sep 3;198(5):769-71. doi: 10.1083/jcb.201207197.
Rho family small GTPases (Rac, RhoA, and Cdc42) function at the core of cytokinesis, the physical division of one cell into two. In this issue, Bastos et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201204107) identify a new role for Rac inhibition: to release cell adhesion at the division plane and allow efficient constriction of the contractile ring. They show that the GTPase-activating protein, CYK4, suppresses equatorial cell substrate adhesion by inhibiting Rac and therefore its effectors ARFGEF7 and PAK1/2.
Rho 家族小 GTPases（Rac、RhoA 和 Cdc42）在胞质分裂（将一个细胞物理分割成两个）的核心功能中起作用。在本期杂志中，Bastos 等人（2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201204107）确定了 Rac 抑制的一个新作用：在分裂平面释放细胞黏附，从而允许收缩环的有效收缩。他们表明，GTP 酶激活蛋白 CYK4 通过抑制 Rac 及其效应物 ARFGEF7 和 PAK1/2 来抑制赤道细胞基底黏附。
