Cohan N, Sarikhani S, Moslemi S, Karimi M
Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Iran Red Crescent Med J. 2011 Jan;13(1):52-4. Epub 2011 Jan 1.
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different factors including the disease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate, corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedic conditions and pain may be the first manifestation of acute leukemia and it is important for physicians to recognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverse effect on survival. We present a child with ALL that refer with multi bone fractures as a first manifestation of the disease.
急性淋巴细胞白血病（ALL）是儿童期最常见的恶性肿瘤。已有报道称ALL与骨骼异常有关，包括骨质疏松和骨折。多种因素可能导致这些患者骨稳态受损，其中包括疾病本身、恶性细胞的可溶性产物以及细胞毒性药物、甲氨蝶呤、皮质类固醇和放疗等治疗药物。骨科疾病和疼痛可能是急性白血病的首发表现，由于诊断延迟会对生存率产生不利影响，因此医生认识到儿童急性白血病的骨骼表现非常重要。我们报告了一名以多处骨折为ALL首发表现前来就诊的儿童。
