Hao Han-Zhou, Chen Tong-Bin, Wu Ji-Liang, Lei Mei, Tian Hui, Zu Wen-Pu, Zhong Xue-Bin
Resources and Environment College, Hubei University of Science and Technology, Xianning 437100, China.
Huan Jing Ke Xue. 2012 Jun;33(6):2075-82.
70 sampling points were set in Wuhan City to collect soil, dust, air and food samples. According to the U. S. EPA recommended childhood lead exposure parameters, U. S. EPA human exposure risk assessment method was used to assess the potential health risk of different pathway exposures of children in Wuhan City to lead. The results of calculation show: Wuhan urban children's daily lead exposure is 1.20 x 10(-3) mg x (kg x d)(-1). The digestive tract is the main way for children's exposure to lead, with the exposure of 1.04 x 10(-3) mg x (kg x d)(-1), followed by the respiratory route and dermal absorption route, the exposures were 0.153 x 10(-3) mg x (kg x d)(-1) and 8.56 x 10(-7) mg x (kg x d)(-1) respectively. Pathways of the digestive tract, ingestion of soil or dust lead exposure accounted for 52.0% of the total exposure, through the digestive tract of soil or dust ingestion is the main route of exposure. Monte-Carlo method was used to simulate the pathway in the digestive tract, the amount of lead exposure through ingestion of soil was 2. 48 x 10(-2) mg x d(-1). The probability that exceeded the PTDI (Provisional Tolerable Daily Intake) specified by JECFA (The Joint FAO/WHO Expert Committee on Food Additives) was 2.1%. The results of the risk assessment indicate that lead exposure risks from the digestive tract, respiratory tract, skin absorption are less than the maximum acceptable risk level 5.0 x 10(-5) respectively and the risk associated with skin absorption of lead is less than the negligible risk level 1 x 10(-8). Application of Kriging interpolation method, Wuhan City children lead exposure value on spatial distribution were obtained, and Qingshan district and Jiangan district have a high level of children lead exposure. The aggregate risk index of Wuhan City children lead exposure was yield by using the indicator Kriging.
在武汉市设置了70个采样点,采集土壤、灰尘、空气和食物样本。依据美国环保署推荐的儿童铅暴露参数,采用美国环保署人体暴露风险评估方法,对武汉市儿童不同途径铅暴露的潜在健康风险进行评估。计算结果表明:武汉市城区儿童每日铅暴露量为1.20×10⁻³毫克/(千克·天)。消化道是儿童铅暴露的主要途径,暴露量为1.04×10⁻³毫克/(千克·天),其次是呼吸道途径和皮肤吸收途径,暴露量分别为0.153×10⁻³毫克/(千克·天)和8.56×10⁻⁷毫克/(千克·天)。消化道途径中,经土壤或灰尘摄入的铅暴露占总暴露量的52.0%,经消化道摄入土壤或灰尘是主要暴露途径。采用蒙特卡洛方法模拟消化道途径,经土壤摄入的铅暴露量为2.48×10⁻²毫克/天。超过食品添加剂联合专家委员会(JECFA)规定的暂定每日耐受摄入量(PTDI)的概率为2.1%。风险评估结果表明,消化道、呼吸道、皮肤吸收途径的铅暴露风险分别小于最大可接受风险水平5.0×10⁻⁵,且铅皮肤吸收相关风险小于可忽略风险水平1×10⁻⁸。应用克里金插值法,得到了武汉市儿童铅暴露值的空间分布情况,青山区和江岸区儿童铅暴露水平较高。利用指示克里金法得出了武汉市儿童铅暴露的综合风险指数。