Nosenko N D, Tarasenko L V, Sinitsyn P V, Sachyns'ka O V, Hanzhyĭ I Iu, Reznikov O H
Fiziol Zh (1994). 2012;58(3):3-8.
The dynamics of blood plasma corticosterone, testosterone and androstenedione levels and their reaction to acute stress (30 min immobilization) in 35-, 40- and 45-day old female rats exposed to chronic stress (daily 30-min immobilization from 35th to 45th day of life) and/or to excess of exogenous androgens (implantation of capsules with testosterone to 33-day old animals) during pubescence was studied. Both control and experimental females in all age groups responded to acute stress by significant elevation of blood plasma corticosterone levels. At the end of the chronic stress session, the extent of adrenals activation in response to acute dosed stress was lowered in androgenized 45-day old females and increased gradually in stressed ones. After acute stress, the blood plasma testosterone level decreased in control 35-day old females and rose - in androgenized females against 10-fold rising of basal hormonal level. In 40-day old control females as well as in androgenized ones exposed to chronic stress during 5 days, the acute dosed stress did not result in significant changes of blood plasma testosterone and elevated blood plasma androstenedione. Stressed 40-day old females with increased basal androstenedione secretion did not respond to acute stress by the hormone level changes while blood plasma testosterone declined significantly. At the end ofpubescence (on the 45th day of life), acute stress did not affect the blood plasma testosterone level in control and androgenized animals, while decreased it in stressed females and increased - in androgenized rats exposed to chronic stress against elevated basal level of the hormone. The conclusion is made about possible functional relationship between the changes in hormonal homeostasis during pubescence and development of reproductive system in mature animals.
研究了35日龄、40日龄和45日龄雌性大鼠在青春期暴露于慢性应激（从出生第35天到第45天每天固定30分钟）和/或暴露于过量外源性雄激素（给33日龄动物植入含睾酮的胶囊）时血浆皮质酮、睾酮和雄烯二酮水平的动态变化及其对急性应激（固定30分钟）的反应。所有年龄组的对照和实验雌性大鼠对急性应激的反应都是血浆皮质酮水平显著升高。在慢性应激期结束时，雄激素化的45日龄雌性大鼠对急性定量应激的肾上腺激活程度降低，而应激大鼠的肾上腺激活程度逐渐增加。急性应激后，对照的35日龄雌性大鼠血浆睾酮水平下降，而雄激素化雌性大鼠的血浆睾酮水平上升，基础激素水平上升了10倍。在40日龄对照雌性大鼠以及在5天内暴露于慢性应激的雄激素化雌性大鼠中，急性定量应激并未导致血浆睾酮的显著变化，而血浆雄烯二酮升高。基础雄烯二酮分泌增加的应激40日龄雌性大鼠对急性应激没有出现激素水平变化，而血浆睾酮显著下降。在青春期结束时（出生第45天），急性应激对对照和雄激素化动物的血浆睾酮水平没有影响，而在应激雌性大鼠中血浆睾酮水平下降，在暴露于慢性应激的雄激素化大鼠中血浆睾酮水平上升，相对于升高的基础激素水平而言。得出了关于青春期激素稳态变化与成熟动物生殖系统发育之间可能存在功能关系的结论。
