Larsen R Scott, Moresco Anneke, Sauther Michelle L, Cuozzo Frank P
Wildlife Health Center and Department of Medicine & Epidemiology , School of Veterinary Medicine, University of California, Davis, California 95616, USA.
J Zoo Wildl Med. 2011 Mar;42(1):75-87. doi: 10.1638/2010-0144.1.
Telazol has been commonly used for field anesthesia of wild lemurs, including ring-tailed lemurs (Lemur catta). Telazol alone provides good induction, but doesn't cause adequate muscle relaxation and sedation for collecting consistent somatic measurements and high-quality dental impressions that are sometimes needed. Variability in induction response has been seen between individuals that have received similar dosages, with young lemurs seeming to need more anesthetic than mature lemurs. This investigation evaluated Telazol induction in young (2.0-4.9 yr) and mature (> or = 5.0 yr) ring-tailed lemurs and compared postinduction supplementation with medetomidine or medetomidine-butorphanol. Forty-eight lemurs were anesthetized with Telazol administered via blow dart; then, 20 min after darting, they were supplemented via hand injection with either medetomidine (0.04 mg/ kg) or medetomidine-butorphanol (0.04 mg/kg and 0.2 mg/kg, respectively). The odds ratio for young lemurs to need more than one dart for induction, relative to mature lemurs, was 3.8, even though the initial dose of Telazol received by young lemurs (19 +/- 7 mg/kg) was significantly higher than the initial dose administered to mature lemurs (12 +/- 5 mg/kg). The total Telazol dosage was also significantly different between young lemurs (33 +/- 15 mg/kg) and mature lemurs (18 +/- 9 mg/kg). Both medetomidine and medetomidine-butorphanol provided good muscle relaxation and sedation for all procedures. Physiologic values were similar between the two protocols. Oxygen saturation by pulse oximetry was generally good, although there were a few SaO2 values < 90%. Recoveries were smooth, but long. Time to head up was correlated with total Telazol dosage in mature lemurs. In young lemurs, time to standing was correlated with Telazol induction dosage and time of last Telazol administration. Lemurs that received hand injections of Telazol took longer to recover than those that did not. Further refinements are needed to increase induction reliability and to decrease recovery time, particularly in young lemurs.
替来他明已被广泛用于野生狐猴的野外麻醉,包括环尾狐猴(Lemur catta)。单独使用替来他明能产生良好的诱导效果,但对于获取有时所需的一致的身体测量数据和高质量的牙齿印模而言,无法引起足够的肌肉松弛和镇静作用。在接受相似剂量的个体之间,已观察到诱导反应存在差异,幼年狐猴似乎比成年狐猴需要更多的麻醉剂。本研究评估了替来他明对幼年(2.0 - 4.9岁)和成年(≥5.0岁)环尾狐猴的诱导作用,并比较了诱导后用美托咪定或美托咪定 - 布托啡诺进行补充的效果。48只狐猴通过吹管注射替来他明进行麻醉;然后,在注射后20分钟,通过手动注射分别用美托咪定(0.04 mg/kg)或美托咪定 - 布托啡诺(分别为0.04 mg/kg和0.2 mg/kg)进行补充。相对于成年狐猴,幼年狐猴诱导时需要不止一支吹管注射的比值比为3.8,尽管幼年狐猴接受的替来他明初始剂量(19±7 mg/kg)显著高于成年狐猴给予的初始剂量(12±5 mg/kg)。幼年狐猴(33±15 mg/kg)和成年狐猴(18±9 mg/kg)的替来他明总剂量也存在显著差异。美托咪定和美托咪定 - 布托啡诺在所有操作中均提供了良好的肌肉松弛和镇静作用。两种方案的生理值相似。通过脉搏血氧饱和度测定的氧饱和度总体良好,尽管有一些SaO2值<90%。恢复过程平稳,但时间较长。成年狐猴抬头时间与替来他明总剂量相关。在幼年狐猴中,站立时间与替来他明诱导剂量及最后一次替来他明给药时间相关。接受手动注射替来他明的狐猴比未接受注射的狐猴恢复时间更长。需要进一步改进以提高诱导的可靠性并减少恢复时间,特别是在幼年狐猴中。