Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA.
Gerontology. 2012;58(6):524-30. doi: 10.1159/000342204. Epub 2012 Aug 30.
The fungicide rapamycin increases lifespan in eukaryotes by interfering with the activity of a serine/threonine kinase called TOR (target of rapamycin). TOR complex 1 (TORC1) is an essential integrator of cellular nutrient cues, growth signals and cellular metabolism. Here, we review major components of TORC1, its downstream effectors and lifespan studies in various organisms involving these signaling components. In particular, we focus on the role of rapamycin in mitochondrial biogenesis, in metabolic regulation and in the control of reactive oxygen species production.
杀菌剂雷帕霉素通过干扰一种称为 TOR（雷帕霉素的靶标）的丝氨酸/苏氨酸激酶的活性来延长真核生物的寿命。TOR 复合物 1（TORC1）是细胞营养线索、生长信号和细胞代谢的重要整合因子。在这里，我们回顾了 TORC1 的主要组成部分、其下游效应物以及涉及这些信号成分的各种生物体中的寿命研究。特别是，我们专注于雷帕霉素在线粒体生物发生、代谢调节和控制活性氧产生中的作用。
