Inhibition of TORC1 signaling and increased lifespan: gained in translation?
作者信息
Rallis Charalampos, Bähler Jürg
出版信息
Aging (Albany NY). 2013 May;5(5):335-6. doi: 10.18632/aging.100560.
Abstract
摘要
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本文引用的文献
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Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality.营养信号在蛋白质动态平衡中的作用：以牺牲质量为代价增加数量。
Sci Signal. 2013 Apr 16;6(271):ra24. doi: 10.1126/scisignal.2003520.
2
TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast.雷帕霉素和咖啡因抑制 TORC1 信号通路对裂殖酵母寿命、全基因组表达和细胞增殖的影响。
Aging Cell. 2013 Aug;12(4):563-73. doi: 10.1111/acel.12080. Epub 2013 May 2.
3
Answering the ultimate question "what is the proximal cause of aging?".回答终极问题“衰老的近端原因是什么？”
Aging (Albany NY). 2012 Dec;4(12):861-77. doi: 10.18632/aging.100525.
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mTOR signaling in growth control and disease.mTOR 信号在生长控制和疾病中的作用。
Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.
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Hot topics in aging research: protein translation and TOR signaling, 2010.衰老研究的热门话题：蛋白质翻译和 TOR 信号转导，2010 年。
Aging Cell. 2011 Apr;10(2):185-90. doi: 10.1111/j.1474-9726.2010.00665.x. Epub 2011 Jan 20.
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Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.通过裂殖酵母中一种G蛋白偶联葡萄糖受体的葡萄糖信号传导的促衰老作用。
PLoS Genet. 2009 Mar;5(3):e1000408. doi: 10.1371/journal.pgen.1000408. Epub 2009 Mar 6.
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