Ro J Y, Ayala A G, el-Naggar A, Grignon D J, Hogan S F, Howard D R
Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Arch Pathol Lab Med. 1990 Jan;114(1):65-7.
We performed DNA flow-cytometric analysis in three cases of angiomyolipoma of the kidney with lymph node involvement. The primary tumors of the kidneys and tumors in the lymph nodes of all patients contained diploid DNA. All three patients have been monitored for longer than 1 year and have no evidence of recurrence or metastasis. The lack of aneuploidy in both the kidney and the lymph nodes in our patients, although not excluding malignant neoplasia, supports the benign and multifocal nature of this lesion. Larger studies with long-term follow-up are reported to confirm this conclusion.
我们对3例伴有淋巴结受累的肾血管平滑肌脂肪瘤进行了DNA流式细胞术分析。所有患者的肾原发性肿瘤及淋巴结肿瘤均含有二倍体DNA。所有3例患者均已接受了超过1年的监测，无复发或转移迹象。尽管不能排除恶性肿瘤，但我们患者的肾和淋巴结中均缺乏非整倍体，这支持了该病变的良性和多灶性本质。据报道，需要进行更大规模的长期随访研究来证实这一结论。
