Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shougoin, Kyoto, Japan.
J Mater Sci Mater Med. 2012 Dec;23(12):2981-92. doi: 10.1007/s10856-012-4758-4. Epub 2012 Sep 5.
The effects of surface treatment on the bone-bonding properties of Ti metal were examined by both mechanical detaching test and histological observation after implantation into rabbit tibiae for various periods ranging from 4 to 26 weeks. The bone-bonding ability of Ti metal, which is extremely low as it is abraded, was hardly increased by simple heat treatment at 600 °C or treatment with H(2)SO(4)/HCl mixed acid alone, but was markedly increased by the heat treatment after the acid treatment. Even Ti metal that had been previously subjected to NaOH treatment showed considerably high bone-bonding ability after acid and heat treatments. Such high bonding abilities were attributed to their high apatite-forming ability in the body environment. Their high apatite-forming abilities were attributed to a high positive surface charge, and not to the type of crystalline phase or specific roughness of their surfaces. The present study has demonstrated that acid and subsequent heat treatments are effective for conferring stable fixation properties on Ti metal implants.
通过对兔胫骨植入不同时间（4-26 周）后进行机械分离试验和组织学观察，研究了表面处理对钛金属骨结合性能的影响。由于钛金属磨损，其骨结合能力极低，600°C 简单热处理或单独用 H(2)SO(4)/HCl 混合酸处理几乎无法提高其骨结合能力，但酸处理后热处理可显著提高其骨结合能力。即使是先前经过 NaOH 处理的钛金属，经过酸和热处理后也表现出相当高的骨结合能力。这种高结合能力归因于它们在体内环境中具有高的形成磷灰石的能力。它们具有高的形成磷灰石的能力归因于其表面的高正表面电荷，而不是晶体相的类型或其表面的特定粗糙度。本研究表明，酸处理和随后的热处理可有效赋予钛金属植入物稳定的固定性能。
