Kokubo Tadashi, Takadama Hiroaki
Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto, Kasugai, Aichi 487-8501, Japan.
Biomaterials. 2006 May;27(15):2907-15. doi: 10.1016/j.biomaterials.2006.01.017. Epub 2006 Jan 31.
The bone-bonding ability of a material is often evaluated by examining the ability of apatite to form on its surface in a simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma. However, the validity of this method for evaluating bone-bonding ability has not been assessed systematically. Here, the history of SBF, correlation of the ability of apatite to form on various materials in SBF with their in vivo bone bioactivities, and some examples of the development of novel bioactive materials based on apatite formation in SBF are reviewed. It was concluded that examination of apatite formation on a material in SBF is useful for predicting the in vivo bone bioactivity of a material, and the number of animals used in and the duration of animal experiments can be reduced remarkably by using this method.
一种材料的骨结合能力通常通过检测磷灰石在离子浓度几乎等同于人体血浆的模拟体液（SBF）中在其表面形成的能力来评估。然而，这种评估骨结合能力的方法的有效性尚未得到系统评估。在此，回顾了SBF的发展历程、磷灰石在SBF中于各种材料上形成的能力与其体内骨生物活性的相关性，以及基于SBF中磷灰石形成的新型生物活性材料开发的一些实例。得出的结论是，检测材料在SBF中磷灰石的形成对于预测材料的体内骨生物活性是有用的，并且使用这种方法可以显著减少动物实验中使用的动物数量和实验持续时间。
