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Combination antibiotic therapy for empiric and definitive treatment of gram-negative infections: insights from the Society of Infectious Diseases Pharmacists.联合抗生素疗法用于革兰氏阴性感染的经验性和确定性治疗：来自感染性疾病药师学会的见解。
Pharmacotherapy. 2011 Nov;31(11):1073-84. doi: 10.1592/phco.31.11.1073.
2
Biodegradable antibiotic delivery systems.可生物降解的抗生素递送系统。
J Bone Joint Surg Br. 2011 Feb;93(2):151-7. doi: 10.1302/0301-620X.93B2.24933.
3
The effects of oral xylitol administration on bone density in rat femur.口服木糖醇对大鼠股骨骨密度的影响。
Odontology. 2011 Jan;99(1):28-33. doi: 10.1007/s10266-010-0143-2. Epub 2011 Jan 27.
4
Effect of xylitol and other carbon sources on Streptococcus pneumoniae biofilm formation and gene expression in vitro.木糖醇和其他碳源对肺炎链球菌体外生物膜形成和基因表达的影响。
APMIS. 2011 Feb;119(2):135-42. doi: 10.1111/j.1600-0463.2010.02703.x. Epub 2010 Dec 1.
5
Surgical treatment of osteomyelitis.骨髓炎的外科治疗。
Plast Reconstr Surg. 2011 Jan;127 Suppl 1:190S-204S. doi: 10.1097/PRS.0b013e3182025070.
6
Treating osteomyelitis: antibiotics and surgery.治疗骨髓炎：抗生素和手术。
Plast Reconstr Surg. 2011 Jan;127 Suppl 1:177S-187S. doi: 10.1097/PRS.0b013e3182001f0f.
7
Effect of xylitol on an in vitro model of oral biofilm.木糖醇对口腔生物膜体外模型的影响。
Oral Health Prev Dent. 2008;6(4):337-41.
8
Enhancement of antibiotic elution from acrylic bone cement.提高抗生素从丙烯酸骨水泥中的洗脱率。
J Biomed Mater Res B Appl Biomater. 2009 Jul;90(1):467-75. doi: 10.1002/jbm.b.31281.
9
Optimized elution of daptomycin from polymethylmethacrylate beads.达托霉素从聚甲基丙烯酸甲酯微球中的优化洗脱
Antimicrob Agents Chemother. 2009 Jan;53(1):264-6. doi: 10.1128/AAC.00258-08. Epub 2008 Oct 27.
10
Xylitol-supplemented nutrition enhances bacterial killing and prolongs survival of rats in experimental pneumococcal sepsis.补充木糖醇的营养可增强对细菌的杀灭作用，并延长实验性肺炎球菌败血症大鼠的存活时间。
BMC Microbiol. 2008 Mar 11;8:45. doi: 10.1186/1471-2180-8-45.

使用木糖醇增强聚甲基丙烯酸甲酯基抗生素疗法治疗慢性骨髓炎的疗效。

Use of xylitol to enhance the therapeutic efficacy of polymethylmethacrylate-based antibiotic therapy in treatment of chronic osteomyelitis.

机构信息

Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

出版信息

Antimicrob Agents Chemother. 2012 Nov;56(11):5839-44. doi: 10.1128/AAC.01127-12. Epub 2012 Sep 4.

DOI:10.1128/AAC.01127-12
PMID:22948866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3486578/
Abstract

Using a rabbit model of postsurgical osteomyelitis, we demonstrate that incorporation of xylitol into polymethylmethacrylate (PMMA) bone cement enhances the elution of daptomycin under in vivo conditions. We also demonstrate that this can be correlated with an improved therapeutic outcome in the treatment of a chronic bone infection following surgical debridement.

摘要

我们通过兔手术后骨髓炎模型证实，将木糖醇加入聚甲基丙烯酸甲酯（PMMA）骨水泥中可增强体内条件下达托霉素的洗脱。我们还证明，在手术清创后治疗慢性骨感染时，这可以与改善治疗效果相关。