使用木糖醇增强聚甲基丙烯酸甲酯基抗生素疗法治疗慢性骨髓炎的疗效。
Use of xylitol to enhance the therapeutic efficacy of polymethylmethacrylate-based antibiotic therapy in treatment of chronic osteomyelitis.
机构信息
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
出版信息
Antimicrob Agents Chemother. 2012 Nov;56(11):5839-44. doi: 10.1128/AAC.01127-12. Epub 2012 Sep 4.
Abstract
Using a rabbit model of postsurgical osteomyelitis, we demonstrate that incorporation of xylitol into polymethylmethacrylate (PMMA) bone cement enhances the elution of daptomycin under in vivo conditions. We also demonstrate that this can be correlated with an improved therapeutic outcome in the treatment of a chronic bone infection following surgical debridement.
摘要
我们通过兔手术后骨髓炎模型证实，将木糖醇加入聚甲基丙烯酸甲酯（PMMA）骨水泥中可增强体内条件下达托霉素的洗脱。我们还证明，在手术清创后治疗慢性骨感染时，这可以与改善治疗效果相关。
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