Centre for Immunology, Burnet Institute, Monash University, Melbourne, Australia.
J Infect Dis. 2012 Nov 15;206(10):1568-76. doi: 10.1093/infdis/jis544. Epub 2012 Sep 4.
Studies examining the effect of coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) on the HCV-specific immune response in acute HCV infection are limited. This study directly compared acute HCV-specific T-cell responses and cytokine profiles between 20 HIV/HCV-coinfected and 20 HCV-monoinfected subjects, enrolled in the Australian Trial in Acute Hepatitis C (ATAHC), using HCV peptide enzyme-linked immunospot (ELISPOT) and multiplex in vitro cytokine production assays. HIV/HCV coinfection had a detrimental effect on the HCV-specific cytokine production in acute HCV infection, particularly on HCV-specific interferon γ (IFN-γ) production (magnitude P = .004; breadth P = .046), which correlated with peripheral CD4(+) T-cell counts (ρ = 0.605; P = .005) but not with detectable HIV viremia (ρ = 0.152; P = .534).
研究检查人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）合并感染对急性 HCV 感染中 HCV 特异性免疫反应的影响是有限的。本研究直接比较了澳大利亚急性丙型肝炎试验（ATAHC）中 20 例 HIV/HCV 合并感染和 20 例 HCV 单感染患者的急性 HCV 特异性 T 细胞反应和细胞因子谱，使用 HCV 肽酶联免疫斑点（ELISPOT）和多重体外细胞因子产生测定。HIV/HCV 合并感染对急性 HCV 感染中的 HCV 特异性细胞因子产生产生了不利影响，特别是对 HCV 特异性干扰素 γ（IFN-γ）产生（幅度 P=0.004；广度 P=0.046），这与外周血 CD4+T 细胞计数相关（ρ=0.605；P=0.005），但与可检测到的 HIV 病毒载量无关（ρ=0.152；P=0.534）。
