Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan.
J Sep Sci. 2012 Oct;35(20):2822-5. doi: 10.1002/jssc.201200480. Epub 2012 Sep 5.
A method for the rapid screening and determination of amphetamine-type designer drugs in saliva by a novel nib-assisted paper spray-mass spectrometry procedure is described. Under optimized conditions, the limit of detections for amphetamine derivatives (model samples: o-, m-, p-chloroamphetamine and o-, m-, p-fluoroamphetamine, respectively) were determined to 0.1 μg/mL by the nib-assisted paper spray-mass spectrometry method. This method is easier and has a higher sensitivity than similar methodologies, including atmospheric pressure/matrix-assisted laser desorption ionization mass spectrometry and electrospray-assisted laser desorption ionization/mass spectrometry. Data obtained using more classical separation methods, including liquid chromatography and capillary electrophoresis, are also reported.
一种通过新型 nib 辅助纸喷雾质谱程序快速筛选和测定唾液中苯丙胺类兴奋剂的方法。在优化条件下，通过 nib 辅助纸喷雾质谱法测定苯丙胺衍生物（模型样品：邻、间、对氯苯丙胺和邻、间、对氟苯丙胺）的检出限分别为 0.1 μg/mL。与大气压/基质辅助激光解吸电离质谱和电喷雾辅助激光解吸电离/质谱等类似方法相比，该方法更简单，灵敏度更高。还报告了使用更经典的分离方法（包括液相色谱和毛细管电泳）获得的数据。
