Institute for Laboratory Medicine, Fuzhou General Hospital, PLA, Fuzhou, Fujian 350025, P.R. China.
J Cell Biochem. 2013 Feb;114(2):250-5. doi: 10.1002/jcb.24373.
Aptamers are a group of molecules, which can specifically bind, track, and inhibit target molecules, comprising DNA aptamers, RNA aptamers, and peptide aptamers. So far, there are much progress about developing novel aptamers and their expansile applications. This prospect systematically introduces the composition and technological evolution of aptamers, and then focuses on the application of aptamers in cancer diagnosis, imaging, and therapy. Following this, we discuss the potential to harness aptamers in discovering the biomarker of stem cells, which is favorable for us to study the normal developmental or abnormal pathological process of tissue and to deliver drugs into target cells or tissues in the future.
适配体是一组能够特异性结合、跟踪和抑制靶分子的分子，包括 DNA 适配体、RNA 适配体和肽适配体。到目前为止，开发新型适配体及其广泛应用方面已经取得了很大的进展。本文系统地介绍了适配体的组成和技术演变，然后重点介绍了适配体在癌症诊断、成像和治疗中的应用。接下来，我们讨论了利用适配体发现干细胞标志物的潜力，这有利于我们研究组织的正常发育或异常病理过程，并在未来将药物递送到靶细胞或组织中。
