Creasy Dianne, Bube Axel, de Rijk Eveline, Kandori Hitoshi, Kuwahara Maki, Masson Regis, Nolte Thomas, Reams Rachel, Regan Karen, Rehm Sabine, Rogerson Petrina, Whitney Katharine
Huntingdon Life Sciences, East Millstone, New Jersey 08875, USA.
Toxicol Pathol. 2012 Aug;40(6 Suppl):40S-121S. doi: 10.1177/0192623312454337.
The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the male reproductive system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the Internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the male reproductive system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.
国际实验动物病理学术语标准化项目（INHAND）（大鼠和小鼠病变命名与诊断标准国际协调）是欧洲毒理病理学会（ESTP）、英国（BSTP）、日本（JSTP）和北美（STP）毒理病理学会的一项联合倡议，旨在为实验动物的增殖性和非增殖性病变制定国际认可的命名法。本出版物的目的是为实验室大鼠和小鼠雄性生殖系统中观察到的微观病变分类提供标准化命名法和鉴别诊断，并配有彩色显微照片说明一些病变实例。本文件中提出的标准化命名法也可供学会成员在互联网上以电子方式获取（http://goreni.org）。材料来源包括世界各地政府、学术界和工业实验室的组织病理学数据库。内容包括自发病变和老化病变以及接触试验材料引起的病变。广泛接受和使用的实验动物雄性生殖系统病变命名国际协调将减少不同国家监管和科研组织之间的混淆，并提供一种通用语言，以增加和丰富毒理学家和病理学家之间的国际信息交流。
