Renne Roger, Brix Amy, Harkema Jack, Herbert Ron, Kittel Birgit, Lewis David, March Thomas, Nagano Kasuke, Pino Michael, Rittinghausen Susanne, Rosenbruch Martin, Tellier Pierre, Wohrmann Thomas
Roger Renne ToxPath Consulting, Sumner, Washington, USA.
Toxicol Pathol. 2009 Dec;37(7 Suppl):5S-73S. doi: 10.1177/0192623309353423.
The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the respiratory tract of laboratory rats and mice, with color photomicrographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous developmental and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for respiratory tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.
国际实验动物病理学术语和诊断标准协调项目（INHAND）是欧洲毒理病理学会（ESTP）、英国毒理病理学会（BSTP）、日本毒理病理学会（JSTP）和北美毒理病理学会（STP）的一项联合倡议，旨在为实验动物的增殖性和非增殖性病变制定国际认可的命名法。本出版物的目的是为实验室大鼠和小鼠呼吸道中观察到的微观病变分类提供标准化命名法，并配有彩色显微照片来说明一些病变实例。本文件中提出的标准化命名法也可在互联网上以电子形式获取（http://www.goreni.org/）。材料来源包括世界各地政府、学术界和工业实验室的组织病理学数据库。内容包括自发的发育和老化病变以及接触试验材料引起的病变。广泛接受和使用的实验动物呼吸道病变命名法的国际协调将减少不同国家监管和科研组织之间的混淆，并提供一种通用语言，以增加和丰富毒理学家和病理学家之间的国际信息交流。
