Polanski Zbigniew
Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, ul. Gronostajowa 9, 30-387 Krakow, Poland.
Reprod Fertil Dev. 2013;25(3):472-83. doi: 10.1071/RD12145.
The spindle assembly checkpoint (SAC) is a surveillance mechanism that monitors the quality of the spindle during division and blocks anaphase entry in the presence of anomalies that could result in erroneous segregation of the chromosomes. Because human aneuploidy is mainly linked to the erroneous segregation of genetic material in oocytes, the issue of the effectiveness of the SAC in female meiosis is especially important. The present review summarises our understanding of the SAC control of mammalian oocyte meiosis, including its possible impact on the incidence of embryonic aneuploidy. Owing to the peculiarities of cell cycle control in female meiosis, the integration of the SAC within such a specific environment results in several unusual situations, which are also discussed.
纺锤体组装检查点（SAC）是一种监测机制，在细胞分裂过程中监测纺锤体的质量，并在存在可能导致染色体错误分离的异常情况时阻止后期进入。由于人类非整倍体主要与卵母细胞中遗传物质的错误分离有关，因此SAC在雌性减数分裂中的有效性问题尤为重要。本综述总结了我们对哺乳动物卵母细胞减数分裂中SAC控制的理解，包括其对胚胎非整倍体发生率的可能影响。由于雌性减数分裂中细胞周期控制的特殊性，SAC在这种特定环境中的整合导致了几种不同寻常的情况，本文也将对此进行讨论。
