德国图林根州动物收容所的猫和狗中艰难梭菌 PCR 核糖型的流行和分布。
Prevalence and distribution of Clostridium difficile PCR ribotypes in cats and dogs from animal shelters in Thuringia, Germany.
机构信息
Institute of Bacterial Infections and Zoonoses at the Federal Research Institute for Animal Health-Friedrich-Loeffler-Institut, Naumburger Strasse 96a, 07743 Jena, Germany.
出版信息
Anaerobe. 2012 Oct;18(5):484-8. doi: 10.1016/j.anaerobe.2012.08.002. Epub 2012 Aug 24.
Clostridium difficile is an important cause of nosocomial diarrhoea in humans. Pet animals and livestock are discussed as potential natural reservoirs and sources of infection. In this study faecal samples from dogs and cats were collected at 10 animal shelters in Thuringia, Germany. C. difficile was isolated from 9 out of 165 (5.5%) canine and 5 out of 135 (3.7%) feline samples. Five PCR ribotypes (010, 014/020, 039, 045, SLO 066) were identified. PCR ribotypes 010 and 014/020 were detected in more than one shelter and PCR ribotypes 014/020 and 045 were isolated from dogs and cats. MLVA profiles of strains of a PCR ribotype from one shelter were identical or closely related, while strains of the same PCR ribotype from different shelters showed significant differences. This study shows that dogs and cats kept in animal shelters are a reservoir of C. difficile PCR ribotypes which can infect also humans.
艰难梭菌是人类医院获得性腹泻的重要病因。宠物动物和牲畜被认为是潜在的自然储主和感染源。在这项研究中，从德国图林根州的 10 个动物收容所采集了犬和猫的粪便样本。从 165 份犬粪便样本中分离出 9 份（5.5%），从 135 份猫粪便样本中分离出 5 份（3.7%）艰难梭菌。鉴定出 5 种 PCR 核糖体分型（010、014/020、039、045、SLO 066）。010 和 014/020 PCR 核糖体分型在一个以上的收容所中检测到，014/020 和 045 PCR 核糖体分型从犬和猫中分离出来。来自一个收容所的一种 PCR 核糖体型的菌株的 MLVA 谱是相同或密切相关的，而来自不同收容所的相同 PCR 核糖体型的菌株则显示出显著的差异。这项研究表明，收容所中的犬和猫是艰难梭菌 PCR 核糖体型的储主，这些核糖体型也可以感染人类。
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