前往兽医诊所就诊的猫和狗胃肠道中艰难梭菌的携带情况。
Gastrointestinal carriage of Clostridium difficile in cats and dogs attending veterinary clinics.
作者信息
Riley T V, Adams J E, O'Neill G L, Bowman R A
机构信息
Department of Microbiology, University of Western Australia, Nedlands.
出版信息
Epidemiol Infect. 1991 Dec;107(3):659-65. doi: 10.1017/s0950268800049359.
Cats and dogs being treated at two veterinary clinics were investigated for gastrointestinal carriage of Clostridium difficile using selective solid and enrichment media. Thirty-two (39.5%) of 81 stool samples yielded C. difficile. There were significant differences in isolation rates between clinics, 61.0% of animals being positive at one clinic compared to 17.5% at the other (Chi-square, P less than 0.005). Of 29 animals receiving antibiotics, 15 (52.0%) harboured C. difficile while 11 (23.9%) of 46 animals not receiving antibiotics were positive (Chi-square, P less than 0.01). There was no difference in carriage rate between cats (38.1%) and dogs (40.0%). The environment at both veterinary clinics was surveyed for the presence of C. difficile. Fifteen of 20 sites at one clinic were positive compared to 6 of 14 sites at the other clinic. Both cytotoxigenic and noncytotoxigenic isolates of C. difficile were recovered from animals and environmental sites. These findings suggest that household pets may be a potentially significant reservoir of infection with C. difficile.
利用选择性固体培养基和增菌培养基，对两家兽医诊所收治的猫和狗进行艰难梭菌胃肠道携带情况调查。81份粪便样本中有32份（39.5%）检出艰难梭菌。两家诊所的分离率存在显著差异，一家诊所61.0%的动物呈阳性，而另一家诊所为17.5%（卡方检验，P<0.005）。在29只接受抗生素治疗的动物中，15只（52.0%）携带艰难梭菌，而在46只未接受抗生素治疗的动物中，11只（23.9%）呈阳性（卡方检验，P<0.01）。猫（38.1%）和狗（40.0%）的携带率没有差异。对两家兽医诊所的环境进行艰难梭菌检测。一家诊所20个位点中有15个呈阳性，另一家诊所14个位点中有6个呈阳性。从动物和环境位点均分离出细胞毒素产生型和非细胞毒素产生型艰难梭菌。这些发现表明，家养宠物可能是艰难梭菌感染的一个潜在重要传染源。
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