Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Korea.
NeuroRehabilitation. 2012;31(2):143-6. doi: 10.3233/NRE-2012-0783.
We report on a patient with traumatic brain injury who showed neural connection between injured cingulum and pedunculopontine nucleus on diffusion tensor tractography (DTT). A 74-year-old male who had suffered a traffic accident underwent conservative management for subarachnoid haemorrhage. Brain MRI which was performed 6 months after onset showed no specific lesions. On 6-month DTTs for cingulum of the patient, we observed discontinuations of both cingulums above the genu of corpus callosum. However, the left cingulum was connected to the left PPN via a neural tract that passed through the anterior corona radiata and thalamus. The neural connection between the injured cingulum and PPN seems to be a compensatory phenomenon for the destruction of cholinergic pathways from basal forebrain. We believe that this result might suggest one of recovery mechanisms of injured cingulum following brain injury.
我们报告了一例创伤性脑损伤患者，其在弥散张量成像（DTT）上显示出损伤的扣带束和脑桥被盖核之间的神经连接。一名 74 岁男性因交通事故导致蛛网膜下腔出血，接受了保守治疗。发病后 6 个月进行的脑部 MRI 检查未显示出特定病变。在对患者扣带束进行的 6 个月 DTT 检查中，我们观察到胼胝体膝部以上的双侧扣带束中断。然而，左侧扣带束通过穿过前放射冠和丘脑的神经束与左侧 PPN 相连。损伤的扣带束和 PPN 之间的神经连接似乎是基底前脑胆碱能通路破坏的代偿现象。我们认为，这一结果可能提示脑损伤后扣带束恢复的机制之一。
