Hong Ji Heon, Jang Sung Ho
Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Republic of Korea.
Brain Res. 2010 Jul 30;1346:190-4. doi: 10.1016/j.brainres.2010.05.088. Epub 2010 Jun 4.
With the exception of post-mortem brain study, there has been no specific evaluation method for the nucleus basalis of Meynert (NBM) and its cholinergic pathway. In the current study, we attempted to identify the neural pathway from the NBM passing through the cingulum in the human brain, using diffusion tensor tractography (DTT). We recruited 22 healthy volunteers for this study. Diffusion tensor images (DTIs) were scanned using 1.5-T; images of the neural pathway from the NBM passing through the cingulum were obtained using the FMRIB Software Library (FSL). Values for fractional anisotropy (FA), mean diffusivity (MD), and tract volume were measured for the neural pathway. The neural pathway, which originated from the NBM, entered the cingulum, running to the anterior portion of the genu of the corpus callosum in the anterior, superior, and lateral directions. The rest of the pathway was through the cingulum to the splenium, or posteriorly to the retrosplenial area. In terms of fractional anisotropy, mean diffusivity, or tract volume, there were no significant differences between hemispheres (P>0.05). Using a probabilistic tractography technique, we identified the neural pathway from the NBM passing through the cingulum in the human brain. Methodology and data from this study of the neural pathway from the NBM passing through the cingulum will be helpful in elucidation of the pathology of diseases involving the basal forebrain or frontal lobe.
除了尸检脑研究外，目前尚无针对迈内特基底核（NBM）及其胆碱能通路的特异性评估方法。在本研究中，我们尝试使用弥散张量纤维束成像（DTT）来识别在人类大脑中从NBM穿过扣带束的神经通路。我们招募了22名健康志愿者参与本研究。使用1.5-T扫描仪扫描弥散张量图像（DTI）；使用FMRIB软件库（FSL）获得从NBM穿过扣带束的神经通路图像。测量该神经通路的各向异性分数（FA）、平均扩散率（MD）和纤维束体积值。该神经通路起源于NBM，进入扣带束，向前、向上和向外延伸至胼胝体膝部的前部。其余通路则通过扣带束到达压部，或向后延伸至压后皮质区。在各向异性分数、平均扩散率或纤维束体积方面，半球间无显著差异（P>0.05）。我们使用概率纤维束成像技术识别了在人类大脑中从NBM穿过扣带束的神经通路。本研究中关于从NBM穿过扣带束的神经通路的方法和数据将有助于阐明涉及基底前脑或额叶疾病的病理学。
