Karaye Kamilu M, Habib Abdulrazaq G
Department of Medicine, Bayero University & Aminu Kano Teaching Hospital, Nigeria
Department of Medicine, Bayero University & Aminu Kano Teaching Hospital, Nigeria.
Eur J Prev Cardiol. 2014 Jun;21(6):682-91. doi: 10.1177/2047487312460018. Epub 2012 Sep 5.
Dyslipidaemia has been recognized as a major risk factor for cardiovascular diseases. Our objectives were to conduct a systematic review and meta-analysis of published studies to determine the prevalence of dyslipidaemia among hospitalized adult patients with cardiovascular disease in sub-Saharan Africa and to compare between the various cardiovascular disease types. We searched Internet-based search tools and other sources for studies on dyslipidaemia or hypercholesterolaemia among hospitalized adult patients with established cardiovascular disease in sub-Saharan Africa, from 1985 to May 2011. Established cardiovascular disease was defined as ischaemic heart disease, heart failure, stroke or chronic kidney disease. We then assessed for between-study heterogeneity and carried out sensitivity analyses. Study quality was assessed using Downs and Black Checklist and publication bias was considered present when positive in both Egger's and Begg's tests. Restricted analyses were then performed on data from studies on ischaemic heart disease, heart failure and stroke separately. A total of 451 studies were screened and eventually 16 studies were included with a total of 2584 persons. The overall estimate of dyslipidaemia was 38.38% (95% confidence intervals = 26.75-50.0; I(2 )= 96.878; p < 0.001). The prevalence was highest among those with ischaemic heart disease (49.64%) than among those with stroke (26.53%) or heart failure (15.4%; p-values for all comparisons<0.001). Prevalence of dyslipidaemia in subjects with cardiovascular disease including ischaemic heart disease, stroke and heart failure in sub-Saharan Africa was high and similar to what was obtained in Western Europe and North America; highest in subjects with ischaemic heart disease, followed by those with stroke and heart failure.
血脂异常已被公认为心血管疾病的主要危险因素。我们的目标是对已发表的研究进行系统评价和荟萃分析，以确定撒哈拉以南非洲地区住院成年心血管疾病患者中血脂异常的患病率，并比较不同类型心血管疾病之间的情况。我们在基于互联网的搜索工具和其他来源中搜索了1985年至2011年5月期间撒哈拉以南非洲地区确诊为心血管疾病的住院成年患者中血脂异常或高胆固醇血症的研究。确诊的心血管疾病定义为缺血性心脏病、心力衰竭、中风或慢性肾病。然后我们评估了研究间的异质性并进行了敏感性分析。使用唐斯和布莱克清单评估研究质量，当Egger检验和Begg检验均为阳性时认为存在发表偏倚。然后分别对缺血性心脏病、心力衰竭和中风研究的数据进行了限制性分析。共筛选了451项研究，最终纳入16项研究，共2584人。血脂异常的总体估计值为38.38%（95%置信区间=26.75-50.0；I（2）=96.878；p<0.001）。缺血性心脏病患者的患病率（49.64%）高于中风患者（26.53%）或心力衰竭患者（15.4%；所有比较的p值<0.001）。撒哈拉以南非洲地区包括缺血性心脏病、中风和心力衰竭在内的心血管疾病患者中血脂异常的患病率较高，与西欧和北美地区的情况相似；缺血性心脏病患者中患病率最高，其次是中风患者和心力衰竭患者。
