UT Southwestern Medical Center, Dallas, Texas 75390, USA.
Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a006114. doi: 10.1101/cshperspect.a006114.
Pathogens exploit several eukaryotic signaling pathways during an infection. They have evolved specific effectors and toxins to hijack host cell machinery for their own benefit. Signaling molecules are preferentially targeted by pathogens because they globally regulate many cellular processes. Both viruses and bacteria manipulate and control pathways that regulate host cell survival and shape, including MAPK signaling, G-protein signaling, signals controlling cytoskeletal dynamics, and innate immune responses.
病原体在感染过程中会利用几种真核信号通路。它们进化出了特定的效应子和毒素，以劫持宿主细胞的机制为己所用。信号分子是病原体的首选目标，因为它们可以全局调节许多细胞过程。病毒和细菌都会操纵和控制调节宿主细胞存活和形态的途径，包括 MAPK 信号、G 蛋白信号、控制细胞骨架动态的信号以及先天免疫反应。
