Department of Gastroenterology, Ningbo No. 1 Hospital, Ningbo, China.
PLoS One. 2012;7(8):e44136. doi: 10.1371/journal.pone.0044136. Epub 2012 Aug 31.
Growth hormone (GH) is an important regulator of metabolism and body composition. GH deficiency is associated with increased visceral body fat and other features of the metabolic syndrome. Here we performed a cross-sectional study to explore the association of GH levels with nonalcoholic fatty liver disease (NAFLD), which is considered to be the hepatic manifestation of the metabolic syndrome. A total of 1,667 subjects were diagnosed as NAFLD according the diagnostic criteria, and 5,479 subjects were defined as the controls. The subjects with NAFLD had significantly lower levels of serum GH than the controls. Those with low GH levels had a higher prevalence of NAFLD and the metabolic syndrome. A stepwise logistic regression analysis showed that GH levels were significantly associated with the risk factor for NAFLD (OR = 0.651, 95%CI = 0.574-0.738, P<0.001). Our results showed a significant association between lower serum GH levels and NAFLD.
生长激素（GH）是代谢和身体成分的重要调节剂。GH 缺乏与内脏体脂肪增加和代谢综合征的其他特征有关。在这里，我们进行了一项横断面研究，以探讨 GH 水平与非酒精性脂肪性肝病（NAFLD）的关系，NAFLD 被认为是代谢综合征的肝脏表现。根据诊断标准，共有 1667 名受试者被诊断为 NAFLD，5479 名受试者被定义为对照组。患有 NAFLD 的受试者血清 GH 水平明显低于对照组。GH 水平较低的患者 NAFLD 和代谢综合征的患病率更高。逐步逻辑回归分析表明，GH 水平与 NAFLD 的危险因素显著相关（OR=0.651，95%CI=0.574-0.738，P<0.001）。我们的结果表明，血清 GH 水平较低与 NAFLD 之间存在显著关联。
