Kleophas W, Leschke M, Tschöpe D, Martin J, Schauseil S, Schottenfeld Y, Strauer B E, Gries F A
Diabetes-Forschungsinstitut, Universität Düsseldorf.
Dtsch Med Wochenschr. 1990 Jan 5;115(1):3-7. doi: 10.1055/s-2008-1060358.
Long-term intermittent heparin-induced extracorporeal low-density lipoprotein (LDL)-cholesterol precipitation was performed in three men - aged 32, 52 and 56 years - with severe familial hypercholesterolaemia and angiographically demonstrated coronary heart disease. This significantly lowered by 65-70% their LDL-cholesterol concentration and by 48-54% their fibrinogen concentration. Fibrinogen elimination reduced plasma viscosity by 13-14% and clearly raised the transcutaneously measured partial pressure of oxygen by 33-50%. Clinically the improved microcirculation achieved a decrease in angina symptoms: the walking distance of the 52-year-old man increased from about 100 m to 4000 m, the daily need of glyceryl trinitrate falling from an average of 12 to 4 aerosol doses.
对三名患有严重家族性高胆固醇血症且经血管造影证实患有冠心病的男性（年龄分别为32岁、52岁和56岁）进行了长期间歇性肝素诱导的体外低密度脂蛋白（LDL）胆固醇沉淀。这使其LDL胆固醇浓度显著降低了65 - 70%，纤维蛋白原浓度降低了48 - 54%。纤维蛋白原的清除使血浆粘度降低了13 - 14%，并明显使经皮测量的氧分压提高了33 - 50%。临床上，微循环的改善使心绞痛症状减轻：52岁男性的步行距离从约100米增加到4000米，硝酸甘油的每日需求量从平均12剂气雾剂降至4剂。
