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表达线粒体过氧化氢酶的PyMT转基因小鼠中的乳腺肿瘤，巨噬细胞和内皮细胞的标记减少。

Breast tumors in PyMT transgenic mice expressing mitochondrial catalase have decreased labeling for macrophages and endothelial cells.

作者信息

Fatemie Sy, Goh Jorming, Pettan-Brewer Christina, Ladiges Warren

机构信息

Department of Comparative Medicine, University of Washington, Seattle, WA, USA.

出版信息

Pathobiol Aging Age Relat Dis. 2012;2. doi: 10.3402/pba.v2i0.17391. Epub 2012 May 11.

DOI:10.3402/pba.v2i0.17391
PMID:22953034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3417526/
Abstract

We show by immunohistochemical labeling that prominent cell types in the tumor microenvironment of PyMT transgenic mice are tumor-associated macrophages (TAMs) and endothelial cells, and that both populations are decreased in the presence of mitochondrial targeted catalase (mCAT). This observation suggests that mitochondrial ROS can drive tumor invasiveness in conjunction with the presence of TAMs and increased angiogenesis. Since primary PyMT tumor cells expressing mCAT undergo increased apoptosis, mitochondrial antioxidants might be attractive anti-tumor agents.

摘要

我们通过免疫组化标记显示，PyMT转基因小鼠肿瘤微环境中的主要细胞类型是肿瘤相关巨噬细胞（TAM）和内皮细胞，并且在存在线粒体靶向过氧化氢酶（mCAT）的情况下，这两种细胞群体均减少。这一观察结果表明，线粒体活性氧（ROS）可与TAM的存在及血管生成增加共同驱动肿瘤侵袭性。由于表达mCAT的原发性PyMT肿瘤细胞凋亡增加，线粒体抗氧化剂可能是有吸引力的抗肿瘤药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0523/3417526/6c40168de9d5/PBA-2-17391-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0523/3417526/4c031c840bb0/PBA-2-17391-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0523/3417526/b219919795f9/PBA-2-17391-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0523/3417526/9b47044e2e43/PBA-2-17391-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0523/3417526/6c40168de9d5/PBA-2-17391-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0523/3417526/4c031c840bb0/PBA-2-17391-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0523/3417526/b219919795f9/PBA-2-17391-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0523/3417526/9b47044e2e43/PBA-2-17391-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0523/3417526/6c40168de9d5/PBA-2-17391-g004.jpg

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本文引用的文献

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BMC Cancer. 2011 May 23;11:191. doi: 10.1186/1471-2407-11-191.
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A mitochondrial view of aging, reactive oxygen species and metastatic cancer.线粒体视角下的衰老、活性氧和转移性癌症。
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Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases.在多瘤病毒中间T癌蛋白小鼠乳腺癌模型中向恶性肿瘤的进展为人类疾病提供了一个可靠的模型。
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