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肉桂蛋白PF在糖尿病背景下的生物学特性研究：通过全基因组mRNA测序分析获得的机制性见解

Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis.

作者信息

Rafehi Haloom, Ververis Katherine, Balcerczyk Aneta, Ziemann Mark, Ooi Jenny, Hu Sean, Kwa Faith A A, Loveridge Shanon J, Georgiadis George T, El-Osta Assam, Karagiannis Tom C

机构信息

Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, VIC., Australia.

出版信息

Pathobiol Aging Age Relat Dis. 2012;2. doi: 10.3402/pba.v2i0.11905. Epub 2012 Feb 22.

DOI:10.3402/pba.v2i0.11905
PMID:22953038
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3417697/
Abstract

The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF(®), represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.

摘要

肉桂（阴香）对2型糖尿病（一种与年龄相关的慢性疾病）有益作用的证据不断积累，促使这种香料的各种补充剂形式实现了商业化。其中一种补充剂Cinnulin PF(®)，代表了含有相对高水平的双连A型原花青素类黄酮聚合物的水溶性部分。本研究的总体目标是利用全基因组mRNA测序分析，来表征Cinnulin PF在永生化人角质形成细胞和微血管内皮细胞中引起的基因表达变化，这些细胞与糖尿病并发症相关。总之，我们的研究结果为Cinnulin PF在糖尿病及糖尿病并发症中的作用机制提供了见解。更广泛地说，我们确定了相关的候选基因，可为进一步研究提供基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/8c3d4a1ac2cd/PBA-2-11905-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/61a052f027fa/PBA-2-11905-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/56b7acfc2d79/PBA-2-11905-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/d8fa8608d0a4/PBA-2-11905-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/5ab2196dc872/PBA-2-11905-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/eed8b54fe2f4/PBA-2-11905-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/49a0d5711c5d/PBA-2-11905-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/8c3d4a1ac2cd/PBA-2-11905-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/61a052f027fa/PBA-2-11905-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/56b7acfc2d79/PBA-2-11905-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/d8fa8608d0a4/PBA-2-11905-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/5ab2196dc872/PBA-2-11905-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/eed8b54fe2f4/PBA-2-11905-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/49a0d5711c5d/PBA-2-11905-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf79/3417697/8c3d4a1ac2cd/PBA-2-11905-g007.jpg

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