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先天性甲状腺功能减退症患儿长期停用左甲状腺素替代治疗的影响。

Effect of prolonged discontinuation of L-thyroxine replacement in a child with congenital hypothyroidism.

作者信息

Kubicky Rita Ann, Weiner Evan, Carlson Bronwyn, De Luca Francesco

机构信息

Section of Endocrinology and Diabetes, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, PA 19134, USA.

出版信息

Case Rep Endocrinol. 2012;2012:841947. doi: 10.1155/2012/841947. Epub 2012 May 8.

DOI:10.1155/2012/841947
PMID:22953072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3420680/
Abstract

When diagnosed through neonatal screening and treated promptly and adequately, infants with congenital hypothyroidism (CH) experience normal physical growth and neurological development. Here we present a 3-year-old boy diagnosed with CH as a newborn, who was subsequently left untreated and experienced significant growth failure and developmental delay. This case emphasizes the importance of a consistent adherence to treatment in preventing such complications, especially in infancy and early childhood.

摘要

通过新生儿筛查确诊并得到及时、充分治疗的先天性甲状腺功能减退症（CH）患儿，其身体生长和神经发育正常。在此，我们报告一名3岁男孩，他在新生儿期被诊断为CH，但随后未接受治疗，出现了明显的生长发育迟缓。该病例强调了持续坚持治疗对于预防此类并发症的重要性，尤其是在婴儿期和幼儿期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a50/3420680/a9abc614f344/CRIM.ENDOCRINOLOGY2012-841947.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a50/3420680/55763aad9476/CRIM.ENDOCRINOLOGY2012-841947.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a50/3420680/ad9dc205d813/CRIM.ENDOCRINOLOGY2012-841947.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a50/3420680/a9abc614f344/CRIM.ENDOCRINOLOGY2012-841947.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a50/3420680/55763aad9476/CRIM.ENDOCRINOLOGY2012-841947.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a50/3420680/ad9dc205d813/CRIM.ENDOCRINOLOGY2012-841947.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a50/3420680/a9abc614f344/CRIM.ENDOCRINOLOGY2012-841947.003.jpg

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本文引用的文献

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Is the incidence of congenital hypothyroidism really increasing? A 20-year retrospective population-based study in Québec.先天性甲状腺功能减退症的发病率真的在增加吗？魁北克的一项 20 年回顾性基于人群的研究。
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Intellectual and motor development of young adults with congenital hypothyroidism diagnosed by neonatal screening.通过新生儿筛查诊断出的先天性甲状腺功能减退症青年的智力和运动发育
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Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine.早期接受大剂量左甲状腺素治疗的先天性甲状腺功能减退症患儿入学时的认知与行为
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Congenital hypothyroidism: influence of disease severity and L-thyroxine treatment on intellectual, motor, and school-associated outcomes in young adults.先天性甲状腺功能减退症：疾病严重程度和左甲状腺素治疗对年轻成年人智力、运动及学校相关结局的影响。
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