韩国水泥行业工人的癌症死亡率和发病率。
Cancer mortality and incidence in cement industry workers in Korea.
机构信息
Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Incheon, Korea.
出版信息
Saf Health Work. 2011 Sep;2(3):243-9. doi: 10.5491/SHAW.2011.2.3.243. Epub 2011 Sep 30.
OBJECTIVES
Cement contains hexavalent chromium, which is a human carcinogen. However, its effect on cancer seems inconclusive in epidemiologic studies. The aim of this retrospective cohort study was to elucidate the association between dust exposure in the cement industry and cancer occurrence.
METHODS
The cohorts consisted of male workers in 6 Portland cement factories in Korea. Study subjects were classified into five groups by job: quarry, production, maintenance, laboratory, and office work. Cancer mortality and incidence in workers were observed from 1992 to 2007 and 1997-2005, respectively. Standardized mortality ratios and standardized incidence ratios were calculated according to the five job classifications.
RESULTS
There was an increased standardized incidence ratio for stomach cancer of 1.56 (27/17.36, 95% confidence interval: 1.02-2.26) in production workers. The standardized mortality ratio for lung cancer increased in production workers. However, was not statistically significant.
CONCLUSION
Our result suggests a potential association between cement exposure and stomach cancer. Hexavalent chromium contained in cement might be a causative carcinogen.
目的
水泥中含有六价铬，而六价铬是一种人类致癌物质。然而，在流行病学研究中，其致癌作用似乎尚无定论。本回顾性队列研究旨在阐明水泥行业粉尘暴露与癌症发生之间的关系。
方法
该队列包括韩国 6 家波特兰水泥厂的男性工人。研究对象按工作分为 quarry、production、maintenance、laboratory 和 office 五个组别。1992 年至 2007 年观察工人的癌症死亡率，1997 年至 2005 年观察癌症发病率。根据五种工作类型计算标准化死亡率比和标准化发病率比。
结果
生产工人的胃癌标准化发病率比为 1.56（27/17.36，95%置信区间：1.02-2.26），有所增加。生产工人的肺癌标准化死亡率也有所增加，但无统计学意义。
结论
我们的结果表明，水泥暴露与胃癌之间可能存在关联。水泥中含有的六价铬可能是一种致癌物质。
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