Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, ML#7029, Cincinnati, OH 45229-3039, USA.
Clin Perinatol. 2012 Sep;39(3):441-57. doi: 10.1016/j.clp.2012.06.010.
Very preterm infants are commonly exposed to a chronic, often asymptomatic, chorioamnionitis that is diagnosed by histologic evaluation of the placenta only after delivery. The reported effects of these exposures on fetal lungs are inconsistent because exposure to different organisms, durations of exposure, and fetal/maternal responses affect outcomes. In experimental models, chorioamnionitis can both injure and mature the fetal lung and cause immune nodulation. Postnatal care strategies also change how chorioamnionitis relates to clinical outcomes such as bronchopulmonary dysplasia.
极早产儿通常会经历慢性、无症状的绒毛膜羊膜炎，只有在分娩后通过胎盘的组织学评估才能诊断。这些暴露对胎儿肺部的影响报道结果不一致，因为暴露于不同的病原体、暴露时间以及胎儿/母体的反应都会影响结果。在实验模型中，绒毛膜羊膜炎既可以损伤胎儿的肺部，也可以促进其成熟，并导致免疫调节。产后护理策略也会改变绒毛膜羊膜炎与支气管肺发育不良等临床结局的关系。
